基本信息
浏览量:105
职业迁徙
个人简介
Bacterial cell wall synthesis
The bacterial cell wall synthesis pathway is the most accessible essential pathway of bacteria and hence a very important target for antibiotic development. The pathway starts in the cytosol with the synthesis of two UDP-activated precursors UDP-GlcNAc and UDP-MurNAc-pentapeptide (see figure). This is followed by the assembly of the complete peptidoglycan subunit on a polyisoprenoid carrier, undecaprenyl phosphate, resulting in a product called Lipid II, the ultimate peptidoglycan precursor. Lipid II is then transported to the exterior side of the plasma membrane and used by bi-functional penicillin binding proteins (PBPs) for the synthesis of the cell wall. The resulting undecaprenyl pyrophosphate is then recycled back to the cytosol, de-phosphorylated after which it is ready to be used again. Our research mainly focuses on the membrane events of this cycle and the different projects are outlined below.
研究兴趣
论文共 194 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yang Xu,Xiaoqi Wang,Esther A. Zaal,Celia R. Berkers,Joseph H. Lorent, Torben Heise,Ruud Cox,Roland J. Pieters,Eefjan Breukink
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipidsno. 4 (2024): 159467-159467
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANESno. 3 (2024): 184282-184282
CELLno. 19 (2023): 4059-4073.e27
Biochimica et biophysica acta. Biomembranesno. 6 (2023): 184160
BIOPHYSICAL JOURNALno. 23 (2023): 4503-4517
Anish Parmar,Rajamani Lakshminarayanan,Abhishek Iyer,Eunice Tze Leng Goh, Tsz Ying To,Joey Kuok Hoong Yam,Liang Yang,Enas Newire, Maria C. Robertson,Stephen H. Prior,Eefjan Breukink,Annemieke Madder,
European Journal of Medicinal Chemistry (2023): 115853-115853
New Developments in NMR NMR Spectroscopy for Probing Functional Dynamics at Biological Interfacespp.563-582, (2022)
Ying Li,Adrien Boes, Yuanyuan Cui,Shan Zhao, Qingzhen Liao,Han Gong,Eefjan Breukink,Joe Lutkenhaus,Mohammed Terrak,Shishen Du
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn