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MicroRNAs (miRNAs), a large class of short non-coding RNAs found in many plants and animals, often act to inhibit gene expression post-transcriptionally. Approximately 3% of all known human genes encode miRNAs. Important functions for miRNAs in animal development and physiology are emerging. A number of miRNAs have been directly implicated in human disease. We have generated loss-of-function mutations in almost all of the 112 known miRNA genes in the nematode Caenorhabditis elegans. This collection provides the only comprehensive resource for the genetic analysis of individual miRNAs to date. Our main goal is to understand the genetic networks underlying miRNA-dependent control of development.
MicroRNAs (miRNAs), a large class of short non-coding RNAs found in many plants and animals, often act to inhibit gene expression post-transcriptionally. Approximately 3% of all known human genes encode miRNAs. Important functions for miRNAs in animal development and physiology are emerging. A number of miRNAs have been directly implicated in human disease. We have generated loss-of-function mutations in almost all of the 112 known miRNA genes in the nematode Caenorhabditis elegans. This collection provides the only comprehensive resource for the genetic analysis of individual miRNAs to date. Our main goal is to understand the genetic networks underlying miRNA-dependent control of development.
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论文共 243 篇作者统计合作学者相似作者
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Fu Xiang Quah,Miguel Vasconcelos Almeida, Moritz Blumer, Chengwei Ulrika Yuan,Bettina Fischer, Kirsten See, Ben Jackson, Richard Zatta,Bosco Rusuwa,George F. Turner,M. Emília Santos,Hannes Svardal,
biorxiv(2024)
Giulia Saredi,Francesco N. Carelli, Stéphane G. M. Rolland,Giulia Furlan,Sandra Piquet, Alex Appert,Luis Sanchez-Pulido,Jonathan L. Price, Pablo Alcon,Lisa Lampersberger,Anne-Cécile Déclais,Navin B. Ramakrishna,
Nature Structural & Molecular Biologyno. 3 (2024): 523-535
Miguel Vasconcelos Almeida, Moritz Blumer, Chengwei Ulrika Yuan, Pío Sierra,Jonathan L Price, Fu Xiang Quah, Aleksandr Friman, Alexandra Dallaire,Grégoire Vernaz, Audrey L K Putman,Alan M Smith,Domino A Joyce,
bioRxiv : the preprint server for biology (2024)
Bioinformatics (Oxford, England) (2024)
European Heart Journalno. Supplement_2 (2023)
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MOLECULAR SYSTEMS BIOLOGYno. 11 (2023): n/a-n/a
Proceedings of the National Academy of Sciencesno. 5 (2023)
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HORMONE RESEARCH IN PAEDIATRICS (2023): 27-27
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