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个人简介
Dr. Ravussin is a world expert in the conduct of translational research in obesity and type 2 diabetes. Over his more than 30 year career, he has conducted numerous clinical investigations on measures of energy expenditure, body composition, carbohydrate metabolism and biomarkers of aging in health and disease states. More specifically over the past 15 years he has established a wet lab studying skeletal muscle and adipose tissue cross talks and the relationship of these two tissues on inflammation, nutrient partitioning and insulin sensitivity. He has published more than 450 peer reviewed manuscripts in the field of obesity, type 2 diabetes and aging. He has mentored more than 60 postdoctoral fellows. Over the past 10 years he has conducted translational research on the impact of caloric restriction on biomarkers of aging, looked at the impact of weight loss in the cross talk between adipose and skeletal muscle and has conducted randomized clinical trial on the impact of dietary, activity, surgical and pharmacological interventions on insulin sensitivity.
Dr. Ravussin is a world expert in the conduct of translational research in obesity and type 2 diabetes. Over his more than 30 year career, he has conducted numerous clinical investigations on measures of energy expenditure, body composition, carbohydrate metabolism and biomarkers of aging in health and disease states. More specifically over the past 15 years he has established a wet lab studying skeletal muscle and adipose tissue cross talks and the relationship of these two tissues on inflammation, nutrient partitioning and insulin sensitivity. He has published more than 450 peer reviewed manuscripts in the field of obesity, type 2 diabetes and aging. He has mentored more than 60 postdoctoral fellows. Over the past 10 years he has conducted translational research on the impact of caloric restriction on biomarkers of aging, looked at the impact of weight loss in the cross talk between adipose and skeletal muscle and has conducted randomized clinical trial on the impact of dietary, activity, surgical and pharmacological interventions on insulin sensitivity.
SELECTED PUBLICATIONS:
A. Ravussin was the first one to put together the methods of the hyperinsulimic euglycemic clamp and indirect calorimetry to quantify the fate of glucose disposal into glucose oxidation vs. non-oxidative glucose disposal rates.
1. Ravussin E, Bogardus C. Thermogenic response to insulin and glucose infusions in man: a model to evaluate the different components of the thermic effect of carbohydrate. Life Sci. 1982 Nov 1;31(18):2011-8. PubMed PMID: 6757619.
2. Ravussin E, Bogardus C, Schwartz RS, Robbins DC, Wolfe RR, et al. Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Invest. 1983 Sep;72(3):893-902. PubMed PMID: 6350368; PubMed Central PMCID: PMC1129254.
B. Early in his career, Ravussin was involved in the building of the first human respiratory chamber in Lausanne, Switzerland. After building the first North America such chamber at NIDDK in Phoenix, he established for the first time the percentages of total daily energy expenditure accounted for by sleeping metabolic rate, the energy cost of arousal, the thermic effect of food and the energy spent in spontaneous physical activity. Then in combination with the doubly labeled water, he was able to quantify the energy cost (and level) of voluntary physical activity. More importantly, he identified the major physiological and genetic determinants of energy metabolism in humans.
3. Bogardus C, Lillioja S, Ravussin E, Abbott W, Zawadzki JK, et al. Familial dependence of the resting metabolic rate. N Engl J Med. 1986 Jul 10;315(2):96-100. PubMed PMID: 3724804.
4. Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest. 1986 Dec;78(6):1568-78. PubMed PMID: 3782471; PubMed Central PMCID: PMC423919.
5. Ravussin E, Lillioja S, Knowler WC, Christin L, Freymond D, et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med. 1988 Feb 25;318(8):467-72. PubMed PMID: 3340128.
研究兴趣
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