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We study the mechanisms for eating behaviour and reward-based decisions in individual neurons and functional brain systems. We conduct single-neuron recordings in animals performing behavioural tasks for nutrient-defined food rewards. These experiments identify the precise information processing by neurons in key reward structures, including the amygdala. In parallel, we conduct closely related human neuroimaging studies to translate and extend the single-neuron data to human brain systems, real-life eating phenotypes, and inter-individual differences. Our broader goal is to uncover basic neurophysiological reward mechanisms that underlie human eating behaviour and thereby to lay foundations for clinical studies in obesity.
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Putu A. Khorisantono, Fei-Yang Huang,Michael P. F. Sutcliffe,Paul C. Fletcher,I. Sadaf Farooqi,Fabian Grabenhorst
JOURNAL OF NEUROSCIENCEno. 47 (2023): 8000-8017
biorxiv(2021)
The Cognitive Neurosciencespp.631-640, (2020)
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