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Professor Platt obtained a BSc in Zoology at Imperial College University of London and a PhD in animal physiology from the University of Bath. She was a post-doctoral fellow at Washington University Medical School in St Louis, USA. She returned to the UK in 1989 (to the Biochemistry Department, University of Oxford) where she focused on how the abnormal accumulation of glycosphingolipids results in pathology in lysosomal storage diseases.
She was a Lister Institute Senior Research Fellow from 1996-2002. A major focus of her work has been on the development of substrate reduction therapy (SRT) to treat several of these disorders. Proof of principle of SRT was demonstrated in mouse models of these primarily neurodegenerative diseases. Dr Platt’s research, in collaboration with Dr Terry Butters, has led to the development of the approved drug miglustat/Zavesca for glycosphingolipid storage disease therapy.
She was a Lister Institute Senior Research Fellow from 1996-2002. A major focus of her work has been on the development of substrate reduction therapy (SRT) to treat several of these disorders. Proof of principle of SRT was demonstrated in mouse models of these primarily neurodegenerative diseases. Dr Platt’s research, in collaboration with Dr Terry Butters, has led to the development of the approved drug miglustat/Zavesca for glycosphingolipid storage disease therapy.
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Tarekegn Geberhiwot,Antonio Ochoa-Ferraro, Andrew Cook,Frances Platt,Kerri-Lee Wallom, Nicola Condon
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
Thamali Ayagama, Philip D Charles,Samuel J Bose,Barry Boland,David A Priestman,Daniel Aston,Georgina Berridge,Roman Fischer,Adam P Cribbs, Qianqian Song,Gary R Mirams, Kwabena Amponsah,
iScienceno. 6 (2024): 109609-109609
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
May Christine Malicdan,David R. Adams,P. J. Brooks, Konstantin Dobrenis,William A. Gahl,Bruno Gasnier,Mary E. Hackbarth, Mahin Hossain,Petcharat Leoyklang, Christine Anne-Longin, Liisa Paavola,Frances Platt,
MOLECULAR GENETICS AND METABOLISMno. 2 (2024)
Biochemical Society transactionsno. 5 (2023): 1777-1787
Rumaitha Al Hosni,Emilio Agostinelli,Zeki Ilkan,Lara F Scofano, Kathryn Acheson, Andrew MacDonald, Dean Rivers,Martin Gunthorpe,Frances Platt,Paolo Tammaro
The Journal of biological chemistryno. 8 (2023): 105024-105024
Cellsno. 4 (2023): 347-347
Wellcome Open Research (2023)
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