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We are interested in the genomics of bacteria. Having sequenced E. coli K-12 we have now turned to large scale functional genomics of E. coli through DNA chip analysis of global gene expression and by phenotypic analysis of conditional knock-out mutations.
We are also interested in hypothesis driven comparative and evolutionary genomics by sequencing strains closely related to K-12. The first strain sequenced for comparison is E. coli 0157:H7, the “hamburger strain.” Future studies include enteropathogenic, enterotoxigenic, enteroaggregative and uropathogenic strains of E. coli, as well E. coli K1, a cause of neonatal sepsis and miningitis. We are also planning to sequence Yersinia Pestis (plague), Shigella flexneri (dysentary), and Salmonella typhi (typhoid fever). It turns out that many virulence determinants of the different pathogens are similar pathogens, so this approach will allow identification of a “pathosphere” of the virulence genes that make up the pathogenic potential of these bacteria. Other lab interests include bioinformatics, technology development, and genetic engineering/re-engineering of bacterial genomes.
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MOLECULAR BIOLOGY AND EVOLUTIONno. 5 (2016): 1257-1269
Genetic Engineering & Biotechnology Newsno. 4 (2015): 20-21
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