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Gerard's current research focus takes a translational approach to the assessment of neurpharmacological indices of stress-related disorders such as depression and irritable bowel syndrome (IBS). This approach incorporates studies in both clinical populations and in animal models using early-life stress templates that produce specific disease phenotypes in adulthood. He is particularly interested in the advancing our understanding of how tryptophan degradation along the kynurenine pathway influences psychopathology and in evaluating novel therapeutic interventions which can reverse such deficits. His research also interrogates the impact of microbiota manipulation on the central nervous system. This is a rapidly expanding area of research with enormous potential and one which is studied using the combined approach of germ-free animals, probiotic administration and antibiotic induced dysbiosis. His research has been recognised internationally by travel awards from the European College of Neuropsychopharmacology (ECNP) as well as a prestigious career development award from the American Neurogastroenterology and Motility Society (ANMS) and a NARSAD award from the Brain and Behaviour Research Foundation. In addition, he is currently a principal investigator on a HRB funded study examining the links between kynurenine pathway metabolites and cognitive dysfunction in IBS and has just recently acquired HRB funding to examine the biological burden of caregiving.
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Benjamin Valderrama,David Antoine Lachmansingh,John Cryan,Thomaz Bastiaanssen,Gerard Clarke,Aonghus Lavelle
HRB Open Research (2024)
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Schizophrenia bulletin (2023)
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Clinical pharmacology and therapeuticsno. 2 (2023): 246-259
Journal of Advanced Research (2023)
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