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Dr. Koob also is one of the world’s authorities on the neurobiology of drug addiction. He has contributed to our understanding of the neurocircuitry associated with the acute reinforcing effects of drugs of abuse and more recently on the neuroadaptations of these reward circuits associated with the transition to dependence. He has validated key animal models for dependence associated with drugs of abuse and has begun to explore a key role of anti-reward systems in the development of dependence. The identification of specific neurochemical systems within the basal forebrain system of the extended amygdala involved in motivation has significant theoretical and heuristic impact. From a theoretical perspective, identification of a role for dopaminergic, opioidergic, GABAergic, glutamatergic and corticotropin-releasing factor systems in the excessive drug taking provides a neuropharmacologic basis for the allostatic changes hypothesized to drive the process of pathology associated with addiction, anxiety, and depression. From a heuristic perspective, these findings provide a framework for further molecular, cellular and neurocircuit research that will identify the basis for individual differences in vulnerability to pathology.
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论文共 1148 篇作者统计合作学者相似作者
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Nutrientsno. 10 (2024): 1527
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2024): 173694-173694
Josephin Wagner, Lauren M. Park,Partha Mukhopadhyay,Csaba Matyas,Eszter Trojnar,Ruslan Damadzic,Jeesun Jung,Andrew S. Bell,Lucas A. Mavromatis, Ali M. Hamandi,Daniel B. Rosoff,Leandro F. Vendruscolo,
Amanda Olsen-Dufour,Shiyu Tang,Sung Won Kim, Torben Pearson, Michael Freaney, Nate Burkard,Madeline Jenkins,Adrian Lee,Jeih-San Liow, Paul Parcon,Shawn Wu,Leandro Vendruscolo,
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2024): 255-275
Diana W. Bianchi, Patricia Flatley Brennan,Michael F. Chiang, Lindsey A. Criswell, Rena N. D’Souza,Gary H. Gibbons, James K. Gilman,Joshua A. Gordon,Eric D. Green, Susan Gregurick,Richard J. Hodes, Peter H. Kilmarx,
Nature Medicineno. 2 (2024): 330-333
András H Lékó, Adriana Gregory-Flores,Renata C N Marchette, Juan L Gomez, Janaina C M Vendruscolo,Vez Repunte-Canonigo, Vicky Choung, Sara L Deschaine, Kimberly E Whiting, Shelley N Jackson,Maria Paula Cornejo, Mario Perello,
Communications biologyno. 1 (2024): 632-632
Renata C N Marchette,Erika R Carlson, Emma V Frye,Lyndsay E Hastings,Janaina C M Vendruscolo, Gustavo Mejias-Torres,Stephen J Lewis,Aidan Hampson,Nora D Volkow,Leandro F Vendruscolo,George F Koob
The Journal of pharmacology and experimental therapeuticsno. 2 (2023): 117-134
Rani S Richardson,Agnieszka Sulima,Kenner C Rice, Jed A Kucharczk,Kim D Janda,Khalin E Nisbett,George F Koob,Leandro F Vendruscolo,Lorenzo Leggio
Neuropharmacology (2023): 109643-109643
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