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Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.
Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.
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Memorias do Instituto Oswaldo Cruz (2023): e230033-e230033
Kartika Wardhani,Aviva Levina,Biyun Sun,Georges E R Grau,F Richard Keene,J Grant Collins,Peter A Lay
Chemical communications (Cambridge, England)no. 45 (2023): 6877-6880
International journal of molecular sciencesno. 20 (2023): 15256-15256
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biorxiv(2022)
Florentina Aglas-Leitner,Pierre Juillard, Anette Juillard,Scott N Byrne,Simon Hawke,Georges E Grau,Felix Marsh-Wakefield
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