基本信息
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职业迁徙
个人简介
Postdoctoral, Harvard Medical School, Biological Chemistry & Molecular Pharmacology (2019)
Honors & Awards
Postdoctoral Fellowship, Jane Coffin Childs Memorial Fund (2014-2017)
Outstanding Graduate Student Instructor Award, University of California, Berkeley (2008)
Silver Medal, International Physics Olympiad (2002)
Research in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.
Honors & Awards
Postdoctoral Fellowship, Jane Coffin Childs Memorial Fund (2014-2017)
Outstanding Graduate Student Instructor Award, University of California, Berkeley (2008)
Silver Medal, International Physics Olympiad (2002)
Research in my laboratory is aimed at understanding how eukaryotes replicate their DNA despite numerous challenges (collectively known as replication stress), and more generally – how eukaryotic cells safeguard genome integrity. Specifically, we are investigating: (i) mechanisms that regulate the activity of the replicative helicase during replication stress, (ii) mechanisms that control the inheritance of epigenetic information during replication, and (iii) mechanisms of ubiquitin-mediated regulation of genome maintenance. We utilize single-molecule microscopy to directly image fluorescently-labeled replication factors and track them in real time in Xenopus egg extracts. I developed this system as a postdoctoral fellow, and used it to monitor how the eukaryotic replicative helicase copes with DNA damage. We plan to further extend the capabilities of this platform to directly visualize other essential replication factors, nucleosomes, and regulatory post-translational modifications like ubiquitin chains. By elucidating molecular mechanisms responsible for maintaining genome stability, we aim to better understand the link between genome instability and cancer, and how these mechanisms can be harnessed to improve disease treatment.
研究兴趣
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bioRxiv : the preprint server for biology (2024)
Yang Lim,Lukas Tamayo-Orrego, Ernst Schmid,Zygimante Tarnauskaite,Olga V. Kochenova, Rhian Gruar,Sachiko Muramatsu,Luke Lynch, Aitana Verdu Schlie,Paula L. Carroll,Gheorghe Chistol,Martin A. M. Reijns,
SCIENCEno. 6664 (2023): 1301-+
R. Alex Wu, Daniel R. Semlow,Ashley N. Kamimae-Lanning,Olga V. Kochenova,Gheorghe Chistol,Michael R. Hodskinson, Ravindra Amunugama, Justin L. Sparks,Meng Wang,Lin Deng, Claudia A. Mimoso, Emily Low,
NATUREno. 7747 (2019): 267-272
semanticscholar(2018)
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