基本信息
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职业迁徙
个人简介
My research focuses on studying the structure and dynamics of proteins involved in the blood coagulation cascade in order to explain their function at atomic level of detail. One aspect of my research is understanding how oxidative stress present during inflammation alters the function, stability and binding behavior of blood coagulation factors. In particular, I study the function of von Willebrand Factor, which is essential in slowing down platelets in case of arterial injury and the self-association properties of fibrinogen, which is important to stabilize the blood clot. The main technique that I use is molecular dynamics simulations often combined with accelerated sampling methods or free energy perturbation. Since I believe that it is essential to validate computational results through experiments, I also study the behavior of von Willebrand Factor through a flow chamber assay which mimics the shear forces present in flowing blood. Oxidative stress due to traumatic injury is thought to increase the thrombotic activity of blood coagulation factors.
AWARDS AND HONORS
2013 – National Heart Lung and Blood Institute K25 career development award
2007 – American Heart Association postdoctoral fellowship
2005 – Swiss Science National Foundation postdoctoral fellowship
AWARDS AND HONORS
2013 – National Heart Lung and Blood Institute K25 career development award
2007 – American Heart Association postdoctoral fellowship
2005 – Swiss Science National Foundation postdoctoral fellowship
研究兴趣
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PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICSno. 1 (2024): 117-133
bioRxiv : the preprint server for biology (2024)
biorxiv(2021)
Rachel Tsai,Gianluca Interlandi
semanticscholar(2020)
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