基本信息
浏览量:22
职业迁徙
个人简介
Graham Warren has made major contributions to the understanding of membrane organisation in higher cells, particularly of the Golgi apparatus. By combining biochemistry and electron microscopy, he showed that proteins destined for the plasma membrane pass through each cisterna of this organelle, and demonstrated that it contains at least three distinct functional compartments which can be distinguished by their content of oligosaccharide modifying enzymes. He discovered that one of these enzymes, beta-1,4-galactosyltransferase, is retained in the correct part of the Golgi apparatus by its membrane-spanning domain and flanking regions, and has proposed a model to account for the way in which this is achieved. Graham has elucidated in detail the fate of the Golgi complex during mitosis. He found that transport to the plasma membrane is inhibited, while Golgi cisternae fragment and partition between daughter cells. He has also been at the forefront of efforts to develop cell-free assays to study these and related processes, most notably devising assays that reconstitute all of the early steps on the pathway of receptor-mediated endocytosis.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn