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个人简介
Dr. Morton’s research focuses on studying the role of the brain in the regulation of energy balance and glucose metabolism and how defects in this control system contribute to the development of obesity, insulin resistance and diabetes.
A major focus of Dr. Morton’s research program is to determine the role of the brain in the regulation of energy balance and glucose metabolism. The overarching hypothesis is that the central nervous system (CNS) senses and receives afferent input from hormonal and nutrient-related signals that convey information regarding both short-term and long-term energy availability and energy stores. In response to this input, the brain engages neuroendocrine, autonomic and behavioral responses that regulate energy intake, energy expenditure, glucose production and glucose uptake in order to maintain energy homeostasis and glycemic control. Our current research identifies the CNS mechanisms and neurocircuits that mediate these responses, and how they communicate this to peripheral tissues. To accomplish this, we utilize state-of-the-art neuroscience approaches, including both “optogenetics and DREADD” methodologies to selectively activate and inhibit specific neuronal populations in combination with genetic, molecular and immunohistochemical techniques and comprehensive energy balance and glucose-metabolic phenotyping.
This research work has been continuously funded by the National Institute of Health (NIH), along with current, or previous funding sources from the American Diabetes Association, American Heart Association, Novo Nordisk A/S and the Royalty Research Fund at the University of Washington.
A major focus of Dr. Morton’s research program is to determine the role of the brain in the regulation of energy balance and glucose metabolism. The overarching hypothesis is that the central nervous system (CNS) senses and receives afferent input from hormonal and nutrient-related signals that convey information regarding both short-term and long-term energy availability and energy stores. In response to this input, the brain engages neuroendocrine, autonomic and behavioral responses that regulate energy intake, energy expenditure, glucose production and glucose uptake in order to maintain energy homeostasis and glycemic control. Our current research identifies the CNS mechanisms and neurocircuits that mediate these responses, and how they communicate this to peripheral tissues. To accomplish this, we utilize state-of-the-art neuroscience approaches, including both “optogenetics and DREADD” methodologies to selectively activate and inhibit specific neuronal populations in combination with genetic, molecular and immunohistochemical techniques and comprehensive energy balance and glucose-metabolic phenotyping.
This research work has been continuously funded by the National Institute of Health (NIH), along with current, or previous funding sources from the American Diabetes Association, American Heart Association, Novo Nordisk A/S and the Royalty Research Fund at the University of Washington.
研究兴趣
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Kendra Francis,Hengqi (Betty) Zheng,David Suskind, Mason E. Nuding,Gregory Morton,Michael Schwartz, Kimberly Alonge,Jarrad Scarlett
Gastroenterologyno. 5 (2024): S-1208
Jennifer D Deem,David Tingley, Christina A Watts,Kayoko Ogimoto, Caeley L Bryan,Bao Anh N Phan,Vincent Damian,Michael R Bruchas,Jarrad M Scarlett,Michael W Schwartz,Gregory J Morton
Jennifer D. Deem,David Tingley, Anne-Mette Bjerregaard,Anna Secher,Owen Chan,Chukwuemeka Uzo,Nicole E. Richardson, Elizabeth Giering,Tammy Doan,Bao A. Phan,Brandon Wu,Jarrad M. Scarlett,
DIABETESno. 9 (2023): 1207-1213
Kendra L Francis,Kimberly M Alonge, Maria Cristina Pacheco,Shannon J Hu, Cody A Krutzsch,Gregory J Morton, Michael W Schwartz,Jarrad M Scarlett
World journal of gastroenterologyno. 33 (2023): 4991-5004
Endocrinologyno. 7 (2023)
Jennifer D. Deem,David Tingley, Anne-Mette Bjerregaard,Chelsea L. Faber,Tammy P. Doan,Bao Anh N. Phan, Zainab Nasir,Brandon Wu, Matthew K. Hwang, Asmit Kumar,Jarrad M. Scarlett,Gregory J. Morton,
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