Wei's work focuses on high-speed, low-power digital and mixed-signal circuits. As portable electronics become ever more common, the demand for new ways to make these devices more energy efficient continues to grow. Wei's investigation of novel circuit designs and system-level hardware implementation techniques aims to reduce power consumption by these portable devices. His work to invent new wired communication building blocks is also enabling high-bandwidth communication among these devices.

Wei's research contributions have come in two primary areas: high-speed, low-power communication links and the interface between circuits and architecture. In the area of communication links, he is best known for a novel scheme for clock-data recovery and for introducing dynamic frequency and voltage scaling into I/O systems.