Kroemer discovered that the permeabilization of mitochondrial membranes constitutes a decisive step in programmed cell death, as well as the detailed mechanisms that make cancer cell death immunogenic in the context of successful antineoplastic treatments. In recent years, he has worked on the link between cellular stress and autophagy, as well as the stimulation of autophagy for improving health span and lifespan in model organisms. His more than 1500 publications have been cited >335,000 times (h-index=271) according to Google Scholar and >241,000 times according to the Web of Science (Thomson Reuters) (h-index=230).