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Dr. Broxmeyer's laboratory is interested in blood cell production (hematopoiesis) in the context of normal and abnormal cell regulation as assessed in vitro and in vivo. As a clinical correlate, his laboratory is interested in the use of hematopoietic stem and progenitor cells, especially those from umbilical cord blood, for transplantation purposes, and the use of cytokines/chemokines for treatment of hematological disorders. His laboratory has been involved in studies assessing and establishing the use of cord blood for transplantation, and in vivo effects of cytokines, especially in patients on clinical trial. His group focused recently on the family of molecules called chemokines for enhancement of proliferation, survival, or movement (homing and mobilization) of early subsets of blood cells, alone and in the presence of colony stimulating factors and co-stimulating ligands, stem cell factor and Flt3-ligand.
His laboratory demonstrated that inactivation/deletion of the peptidase activity of CD26/Dipeptidylpeptidase IV on murine and human stem cells greatly enhances their homing and engraftment capability and clinical trials are ongoing to use this to enhance engraftment of cord blood cells.
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Science Advancesno. 2 (2022)
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