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The research in our group is focussed on the development and application of nuclear magnetic resonance (NMR) spectroscopy to study biomacromolecules. Our focus is to contritube to a molecular understanding of fundamental mechanism of biomacromolecules. We investigate proteins - soluble proteins and membrane proteins. We investige RNAs and RNA-protein complexes and unusual DNA structures.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
Particular emphasis is on time-resolved NMR experiments; we induce protein, DNA- or RNA-folding by light from compounds that are caged in one (of several) conformations by photolabile protecting groups or natural light-absorbing chromophors. Some of these caged molecules are synthesized in the lab. A different way of inducing biomacromolecular folding is by temperature jump; thus we have developed T-jump probes to do these kind of experiments.
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论文共 654 篇作者统计合作学者相似作者
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Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland,Sridhar Sreeramulu, Franziska Kinnen, Christian Richter,Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletic, Robert Harmel,
ACS CHEMICAL BIOLOGYno. 3 (2024): 607-618
Nadide Altincekic, Nathalie Joeres,Frank Loehr,Christian Richter, Claus Ehrhardt,Marcel J. J. Blommers,Hannes Berg, Sare Oeztuerk,Santosh L. Gande,Verena Linhard,Julien Orts, Marie Jose Abi Saad,
ACS CHEMICAL BIOLOGYno. 2 (2024): 563-574
Chembiochem : a European journal of chemical biologypp.e202400049-e202400049, (2024)
Tobias Matzel, Maria Wirtz Martin, Alexander Herr,Anna Wacker,Christian Richter,Sridhar Sreeramulu,Harald Schwalbe
RNA (New York, N.Y.) (2024)
Chemical communications (Cambridge, England)no. 25 (2024): 3433-3436
RSC medicinal chemistryno. 1 (2024): 165-177
NUCLEIC ACIDS RESEARCHno. 1 (2024): 87-100
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