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There are two types of adipose tissue. White adipose tissue (WAT) accumulates triglycerides (TAG) as the main energy storage form. Obesity from increased WAT mass with increased TAG storage to enlarge cell size, as well as with increased adipocyte number, has become an epidemic. Obesity is associated various diseases, including type 2 diabetes and cardiovascular diseases. In contrast to WAT, brown adipose tissue (BAT) dissipates energy as heat via non-shivering thermogenesis. Moreover, in certain conditions, subcutaneous WAT can become more like BAT by so-called beiging to perform thermogenesis. Thus, increasing BAT or BAT-like tissues may represent a means to obesity prevention/therapeutics. The broad aims of our research in the Sul Lab are to understand a) regulation of TAG synthesis and breakdown, b) recruitment and differentiation of adipocytes, and 3) development and function of BAT or BAT-like tissues.
There are two types of adipose tissue. White adipose tissue (WAT) accumulates triglycerides (TAG) as the main energy storage form. Obesity from increased WAT mass with increased TAG storage to enlarge cell size, as well as with increased adipocyte number, has become an epidemic. Obesity is associated various diseases, including type 2 diabetes and cardiovascular diseases. In contrast to WAT, brown adipose tissue (BAT) dissipates energy as heat via non-shivering thermogenesis. Moreover, in certain conditions, subcutaneous WAT can become more like BAT by so-called beiging to perform thermogenesis. Thus, increasing BAT or BAT-like tissues may represent a means to obesity prevention/therapeutics. The broad aims of our research in the Sul Lab are to understand a) regulation of TAG synthesis and breakdown, b) recruitment and differentiation of adipocytes, and 3) development and function of BAT or BAT-like tissues.
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Nature communicationsno. 1 (2024): 186-186
Innovation in Agingno. Supplement_1 (2022): 320-321
COMMUNICATIONS BIOLOGYno. 1 (2022): 44-16
FRONTIERS IN ENDOCRINOLOGY (2021)
semanticscholar(2021)
Frontiers in endocrinology (2021): 595020-595020
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