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The brain circuit is an intricately interconnected network of a vast number of neurons with diverse molecular, anatomical and physiological properties. To understand the principles of information processing in the brain circuit, it is essential to have a systematic understanding of the common and unique properties for each of its components - the neuronal cell types, to monitor their activities while the brain is processing information, and to have the ability to manipulate these neurons to investigate their functions in the brain circuit. Combining genetic tools with large-scale imaging and single-cell analysis technologies presents us with the opportunity to gain systematic understanding of the properties, interconnections and functions of these cell types. My team at the Allen Institute for Brain Science has been building multiple platforms, including single-cell transcriptomics, single and multi-patching electrophysiology, 3D reconstruction of neuronal morphology, high throughput brain-wide connectivity mapping, neuronal activity imaging, and cell type-targeted transgenic and viral to characterize the transcriptomic, physiological, morphological, and connectional properties of different types of neurons in a standardized way, towards a taxonomy of cell types and a description of their connectivity matrix for mouse brain circuits such as the visual cortico-thalamic system. Building such a knowledge base lays the foundation towards the understanding of the computational mechanisms of brain circuit function.
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Papers共 268 篇Author StatisticsCo-AuthorSimilar Experts
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Caroline A. McLachlan, David G. Lee, Osung Kwon, Kevin M. Delgado, Nikita Manjrekar,Zizhen Yao,Hongkui Zeng, Bosiljka Tasic, Jerry L. Chen
Cell Reportsno. 1 (2025): 115175
Kelly Jin,Zizhen Yao,Cindy T. J. van Velthoven,Eitan S. Kaplan,Katie Glattfelder, Samuel T. Barlow,Gabriella Boyer,Daniel Carey,Tamara Casper,Anish Bhaswanth Chakka,Rushil Chakrabarty,Michael Clark,Max Departee, Marie Desierto,Amanda Gary,Jessica Gloe,Jeff Goldy,Nathan Guilford,Junitta Guzman,Daniel Hirschstein,Changkyu Lee,Elizabeth Liang,Trangthanh Pham,Melissa Reding,Kara Ronellenfitch,Augustin Ruiz,Josh Sevigny,Nadiya Shapovalova, Lyudmila Shulga,Josef Sulc,Amy Torkelson,Herman Tung,Boaz Levi,Susan M. Sunkin, Nick Dee,Luke Esposito,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng
Natureno. 8049 (2025): 182-196
Cindy T J van Velthoven, Yuan Gao,Michael Kunst,Changkyu Lee,Delissa McMillen,Anish Bhaswanth Chakka,Tamara Casper,Michael Clark,Rushil Chakrabarty,Scott Daniel,Tim Dolbeare,Rebecca Ferrer,Jessica Gloe,Jeff Goldy,Junitta Guzman, Carliana Halterman,Windy Ho, Mike Huang, Katelyn James, Beagan Nguy,Trangthanh Pham,Kara Ronellenfitch,Eric D Thomas,Amy Torkelson,Chelsea M Pagan,Lauren Kruse, Nick Dee,Lydia Ng,Jack Waters,Kimberly A Smith,Bosiljka Tasic,Zizhen Yao,Hongkui Zeng
bioRxiv the preprint server for biology (2024)
Natureno. 8027 (2024): 1092-1100
Avery C Hunker,Morgan E Wirthlin, Gursajan Gill,Nelson J Johansen,Marcus Hooper,Victoria Omstead,Naz Taskin,Natalie Weed,Sara Vargas,Jacqueline L Bendrick,Bryan Gore,Yoav Ben-Simon,Yeme Bishaw,Ximena Opitz-Araya,Refugio A Martinez,Sharon Way,Bargavi Thyagarajan, M Nathaly Lerma, Will Laird, Otto Sven,Raymond E A Sanchez, Jason R Alexander, Avalon Amaya,Adam Amster, Angela Ayala, Pam M Baker, Tyler Barcelli, Stuard Barta,Darren Bertagnolli, Cameron Bielstein,Prajal Bishwakarma,Jessica Bowlus,Gabriella Boyer,Krissy Brouner, Brittny Casian,Tamara Casper,Anish Bhaswanth Chakka,Rushil Chakrabarty,Michael Clark, Kaity Colbert,Scott Daniel, Tim Dawe, Maxwell Departee, Peter DiValentin, Nicholas P Donadio,Nadezhda I Dotson,Deepanjali Dwivedi,Tom Egdorf,Tim Fliss,Amanda Gary,Jeff Goldy,Conor Grasso, Erin L Groce, Kathryn Gudsnuk, Warren Han,Zeb Haradon, Sam Hastings, Olivia Helback, Windy V Ho,Cindy Huang,Tye Johnson, Danielle L Jones,Zoe Juneau, Jaimie Kenney, Madison Leibly, Su Li,Elizabeth Liang, Henry Loeffler, Nicholas A Lusk, Zachary Madigan, Jessica Malloy,Jocelin Malone,Rachel McCue,Jose Melchor,John K Mich, Skyler Moosman,Elyse Morin, Robyn Naidoo,Dakota Newman,Kiet Ngo,Katrina Nguyen, Aaron L Oster,Ben Ouellette, Alana A Oyama, Nick Pena,Trangthanh Pham, Elliot Phillips, Christina Pom,Lydia Potekhina,Shea Ransford,Melissa Reding, Dean F Rette, Cade Reynoldson,Christine Rimorin, Ana Rios Sigler, Dana B Rocha,Kara Ronellenfitch,Augustin Ruiz, Lane Sawyer,Josh Sevigny,Nadiya V Shapovalova, Noah Shepard, Lyudmila Shulga,Sherif Soliman,Brian Staats,Michael J Taormina,Michael Tieu, Yimin Wang, Josh Wilkes, Toren Wood,Thomas Zhou,Ali Williford, Nick Dee,Tyler Mollenkopf,Lydia Ng,Luke Esposito,Brian Kalmbach,Shenqin Yao,Jeanelle Ariza,Shoaib Mufti,Kimberly Smith,Jack Waters,Ina Ersing,Marcella Patrick,Hongkui Zeng,Ed S Lein,Yoshiko Kojima, Greg Horwitz, Scott F Owen,Boaz P Levi,Tanya L Daigle,Bosiljka Tasic,Trygve E Bakken,Jonathan T Ting
bioRxiv the preprint server for biology (2024)
Richard Drexler, Antonia Drinnenberg, Avishai Gavish,Belgin Yalcin,Kiarash Shamardani, Abigail Rogers,Rebecca Mancusi,Kathryn Taylor,Yoon Seok Kim,Pamelyn Woo, Alexandre Ravel, Eva Tatlock, Rayyan Jokhai, Alberto Ayala-Sarmiento, David Rincon-Fernandez,Charu Ramakrishnan,La'Akea Siverts,Tanya Daigle,Bosiljka Tasic,Hongkui Zeng,Joshua Breunig,Kyle Loh,Karl Deisseroth,Michelle Monje
NEURO-ONCOLOGY (2024)
Linus Manubens-Gil,Zhi Zhou,Hanbo Chen,Arvind Ramanathan,Xiaoxiao Liu,Yufeng Liu,Alessandro Bria,Todd Gillette,Zongcai Ruan,Jian Yang,Miroslav Radojević,Ting Zhao,Li Cheng,Lei Qu,Siqi Liu,Kristofer E. Bouchard,Lin Gu,Weidong Cai,Shuiwang Ji,Badrinath Roysam,Ching-Wei Wang,Hongchuan Yu,Amos Sironi,Daniel Maxim Iascone,Jie Zhou,Erhan Bas,Eduardo Conde-Sousa,Paulo Aguiar,Xiang Li,Yujie Li,Sumit Nanda,Yuan Wang,Leila Muresan,Pascal Fua,Bing Ye,Hai-yan He,Jochen F. Staiger,Manuel Peter,Daniel N. Cox,Michel Simonneau,Marcel Oberlaender,Gregory Jefferis,Kei Ito,Paloma Gonzalez-Bellido,Jinhyun Kim,Edwin Rubel,Hollis T. Cline,Hongkui Zeng,Aljoscha Nern,Ann-Shyn Chiang,Jianhua Yao,Jane Roskams,Rick Livesey,Janine Stevens,Tianming Liu,Chinh Dang,Yike Guo,Ning Zhong,Georgia Tourassi,Sean Hill,Michael Hawrylycz,Christof Koch,Erik Meijering,Giorgio A. Ascoli,Hanchuan Peng
NATURE NEUROSCIENCEno. 2 (2024): 373-383
Yoav Ben-Simon,Marcus Hooper, Sujatha Narayan,Tanya Daigle,Deepanjali Dwivedi,Sharon W Way, Aaron Oster,David A Stafford,John K Mich,Michael J Taormina,Refugio A Martinez,Ximena Opitz-Araya, Jada R Roth, Shona Allen, Angela Ayala,Trygve E Bakken, Tyler Barcelli, Stuard Barta,Jacqueline Bendrick,Darren Bertagnolli,Jessica Bowlus,Gabriella Boyer,Krissy Brouner, Brittny Casian,Tamara Casper, Anish B Chakka,Rushil Chakrabarty,Rebecca K Chance, Sakshi Chavan, Maxwell Departee,Nicholas Donadio,Nadezhda Dotson,Tom Egdorf,Mariano Gabitto, Jazmin Garcia,Amanda Gary, Molly Gasperini,Jeff Goldy,Bryan B Gore,Lucas Graybuck, Noah Greisman, Francoise Haeseleer, Carliana Halterman, Olivia Helback,Dirk Hockemeyer,Cindy Huang, Sydney Huff,Avery Hunker,Nelson Johansen,Zoe Juneau,Brian Kalmbach, Shannon Khem, Emily Kussick, Rana Kutsal,Rachael Larsen,Changkyu Lee,Angus Y Lee, Madison Leibly,Garreck H Lenz,Elizabeth Liang,Nicholas Lusk,Jocelin Malone,Tyler Mollenkopf,Elyse Morin,Dakota Newman,Lydia Ng,Kiet Ngo,Victoria Omstead, Alana Oyama,Trangthanh Pham,Christina A Pom,Lydia Potekhina,Shea Ransford, Dean Rette,Christine Rimorin, Dana Rocha,Augustin Ruiz,Raymond E A Sanchez,Adriana Sedeno-Cortes, Joshua P Sevigny,Nadiya Shapovalova, Lyudmila Shulga, Ana R Sigler,La' Akea Siverts,Saroja Somasundaram, Kaiya Stewart,Eric Szelenyi,Michael Tieu, Cameron Trader,Cindy T J van Velthoven,Miranda Walker,Natalie Weed,Morgan Wirthlin, Toren Wood, Brooke Wynalda,Zizhen Yao,Thomas Zhou,Jeanelle Ariza, Nick Dee,Melissa Reding,Kara Ronellenfitch,Shoaib Mufti,Susan M Sunkin,Kimberly A Smith,Luke Esposito,Jack Waters,Bargavi Thyagarajan,Shenqin Yao,Ed S Lein,Hongkui Zeng,Boaz P Levi,John Ngai,Jonathan Ting,Bosiljka Tasic
bioRxiv the preprint server for biology (2024)
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Author Statistics
#Papers: 259
#Citation: 34958
H-Index: 79
G-Index: 186
Sociability: 8
Diversity: 3
Activity: 153
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