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Our laboratory is interested in understanding how neural systems encode time and generate rhythmic physiological and behavioral outputs to adapt to the temporal structure of the environment. We use a comparative approach that capitalizes on animal models that range from the laboratory mouse to humans.
Virtually all living species have biological clocks that generate and control the daily cyclic variations in physiology and behavior, such us the sleep-wake cycle, rhythms in locomotor activity, core body temperature and hormonal secretion. In mammals, the master control of these so-called circadian rhythms is exerted by a biological clock located within the suprachiasmatic nucleus (SCN) of the brain. We use behavioral, physiological and molecular techniques in order to understand how the SCN, in concert with other circadian oscillators in the brain, generates and orchestrates this array of circadian rhythms. We also study human circadian rhthms through non-invasive methods to assess the effect of electric light and the urban environment on the timing and quality of sleep.
Virtually all living species have biological clocks that generate and control the daily cyclic variations in physiology and behavior, such us the sleep-wake cycle, rhythms in locomotor activity, core body temperature and hormonal secretion. In mammals, the master control of these so-called circadian rhythms is exerted by a biological clock located within the suprachiasmatic nucleus (SCN) of the brain. We use behavioral, physiological and molecular techniques in order to understand how the SCN, in concert with other circadian oscillators in the brain, generates and orchestrates this array of circadian rhythms. We also study human circadian rhthms through non-invasive methods to assess the effect of electric light and the urban environment on the timing and quality of sleep.
研究兴趣
论文共 118 篇作者统计合作学者相似作者
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H. Craig Heller,Erik Herzog, Allison Brager,Gina Poe,Ravi Allada, Frank Scheer,Mary Carskadon,Horacio O. de la Iglesia, Rockelle Jang,Ashley Montero,Kenneth Wright, Philippe Mouraine,
JOURNAL OF BIOLOGICAL RHYTHMSno. 1 (2024): 5-19
Ivana L Bussi,Miriam Ben-Hamo, Luis E Salazar Leon,Leandro P Casiraghi, Victor Y Zhang, Alexandra F Neitz, Jeffrey Lee,Joseph S Takahashi,Jeansok J Kim,Horacio O de la Iglesia
Proceedings of the National Academy of Sciences of the United States of Americano. 13 (2024): e2316841121-e2316841121
Developments in primatologypp.375-390, (2023)
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Developments in primatologypp.301-321, (2023)
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Fernando M. Louzada, Affonso H.A. Cesar-Silva,Claudia R.C. Moreno,Carolina V.M. Azevedo,Leandro P. Casiraghi,Horacio O. de la Iglesia
Sleep health (2023)
Alicia D. Rice, Olivia Sather,Kenneth P. Wright,Celine Vetter,Melanie A. Martin,Horacio O. de la Iglesia
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2023): 148-149
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Research square (2023)
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