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Like all cells of hematopoietic origin, new T lymphocytes must be generated throughout life, a task that is the primary function of the thymus. Unlike other tissues that undergo steady-state differentiation, however, the thymus contains no self-renewing progenitor cells. Instead, new progenitors are specifically recruited from a pool of multi-potent progenitors that circulate within the blood. Once inside the thymus, these progenitors undergo a series of cell divisions to generate a large pool of T-lineage restricted cells that undergo selection based on the specificity of their antigen receptors, and are ultimately exported to the peripheral immune system. Our laboratory focuses on the early aspects of the intrathymic differentiation process, particularly on those aspects that relate to thymic homing, proliferative expansion, and T lineage commitment. In recent years, we have shown that different phases of these processes take place in specific tissue regions within the thymus, indicating the presence of different signaling microenvironments in the thymus, and obligating the existence of a system for moving progenitors between them.
Like all cells of hematopoietic origin, new T lymphocytes must be generated throughout life, a task that is the primary function of the thymus. Unlike other tissues that undergo steady-state differentiation, however, the thymus contains no self-renewing progenitor cells. Instead, new progenitors are specifically recruited from a pool of multi-potent progenitors that circulate within the blood. Once inside the thymus, these progenitors undergo a series of cell divisions to generate a large pool of T-lineage restricted cells that undergo selection based on the specificity of their antigen receptors, and are ultimately exported to the peripheral immune system. Our laboratory focuses on the early aspects of the intrathymic differentiation process, particularly on those aspects that relate to thymic homing, proliferative expansion, and T lineage commitment. In recent years, we have shown that different phases of these processes take place in specific tissue regions within the thymus, indicating the presence of different signaling microenvironments in the thymus, and obligating the existence of a system for moving progenitors between them.
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2012)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2012)
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