基本信息
浏览量:181
职业迁徙
个人简介
Ichiro Sora, M.D., Ph.D. is Professor and Chairperson, Department of Biological Psychiatry, Tohoku University Graduate School of Medicine since 2002. Dr. Sora is also guest researcher at National Institute on Drug abuse, USA since 1999. He provides government service as members of advisory committees such as regulation of addictive drug, pharmaceutical and medical safety since 2006. Dr. Sora is trained as a psychiatrist (MD, 1982, PhD, 1986 Okayama University Medical School). His current research examines issues in molecular neurobiology of mental disorders. Dr. Sora is principle investigator of the major study of drug abuse, schizophrenia and attention deficit hyperactive disorder, funded by government grants from MHLW and MEXT.
Introduction of Research
It is very useful to develop animal models of neuropsychiatric disorder, which are able to investigate pathophysiology, responsability to medication, and various symptoms of neuropsychiatiric disorder, although there are no sufficient animal models to reflect overall symptoms of psychiatric patients. Recently molecular genetic method, which targets specific genes of mice and delete them, has been established. We introduce here usefulness and recent acknowledgement of these knockout mice as animal models of neuropsychiatric disorder. 。。 Monoamine neurotransmission is affected by antipsychotics or antidepressants, so it is said to play a crucial role in pathophysiology of neuropsychiatric disorders. Dopamine transporter(DAT), serotonin transporter(SERT), and norepinephrine transporter are located on plasma membrane of pre-synaptic region. They rapidly reuptake extracellular monoamine and regulate the neurotransmission.
Drugs of abuse are able to elicit compulsive drug-seeking behaviors upon repeated administration,which ultimately leads to the phenomenon of addiction. Evidence indicates indicates that the susceptibility to develop addiction is influenced by sources of reinforcement, variable neuroadaptive mechanisms, and neurochemical changes that together lead to altered homeostasis of the brain reward system. Addiction is hypothesized to be a cycle of progressive dysregulation of the brain reward system that results in the compulsive use and loss of control over drug taking and the initiation of behaviors associated with drug seeking. Cocaine, amphetamine, and many other psychostimulants are believed to produce their stimulating and addictive effects mainly by increasing the extracellular levels of dopamine in the brain reward areas through the interaction with DAT. Mice lacking DAT are hyperactive and psychostimulants do not increase futher their locomotor activity. However, these mice still self-administer cocaine, as well as show conditioned place preference for cocaine, indicating that the drug's rewarding effects are not abolished. These data showed that although both DAT and SERT participate in cocaine's reward, DAT has more important role in this drug's effect. Studies in monoamine transporter knockout mice paint a picture of considerable complexity in the actions of cocaine.
Articles
Uhl GR, Li S, Takahashi N, Itokawa K, Lin Z, Hazama M, Sora I. The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J 14: 2459-2465 (2000)
Sora I, Hall FS, Andrews AM, Itokawa M, Li XF, Wei HB, Wichems C, Lesch KP, Murphy DL, Uhl GR. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci USA 98: 5300-5305 (2001)
Ikeda K, Ide S, Han W, Hayashida M, Uhl GR, Sora I. How individual sensitivity to opiates can be predicted by gene analyses. Trends Pharmacol Sci 26(6): 311-317 (2005)
Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K,Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I. Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J 6(3):179-188 (2006)
Yamashita M, Fukushima S, Shen H, Hall FS, Uhl GR, Numachi Y, Kobayashi H, Sora I. Norepinephrine Transporter Blockade Can Normalize the Prepulse Inhibition Deficits Found in Dopamine Transporter Knockout Mice. Neuropsychopharmacology 31(10):2132-2139. (2006)
研究兴趣
论文共 296 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Takeshi Kojina,Kayano Yotsumoto, Yuko Nishimura, Tomoe Ebisu,Tadasu Horai, Shinsuke Aoyama,Ichiro Sora,Takeshi Hashimoto
Takaki Tanifuji,Ikuo Otsuka,Satoshi Okazaki,Tadasu Horai,Ryuhei So, Kyoichi Shiroiwa,Kentaro Mouri,Motofumi Tanaka, Nobuko Ohmoto,Ichiro Sora,Midori Hirai,Takumi Fukumoto,
Neuropsychopharmacology Reportsno. 2 (2022): 174-182
引用1浏览0引用
1
0
Psychiatry and Clinical Neurosciences Reportsno. 1 (2022): n/a-n/a
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn