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Best known for his pivotal gene therapy discoveries, Dr. Verma is a global authority on the development of viral gene therapy vectors such as those developed by he and his colleagues using a modified form of HIV. Using this vector, he successfully delivered therapeutic genes into preclinical animal models. He was among the first to demonstrate the feasibility of gene therapy using a retroviral vector and provided the foundation on which many current investigational gene therapy approaches are based.
Through his research, Dr. Verma has worked to create a superior mouse model of cancer by utilizing modified viruses to effectively deliver activated oncogenes to specific target cells within immunocompetent mice. By using this approach to promote carcinogenesis, Dr. Verma and his team have been able to uncover valuable new insights into the genetic etiologies of various cancers.
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