Irfan Rahman
教授
Department of Public Health Sciences
University of Rochester Medical Center;Environmental Health Sciences Center, University of Rochester Medical Center;Center for Inhalation and Flavoring Toxicological Research, University of Rochester Medical Center;Department of Environmental Medicine, University of Rochester Medical Center;Department of Medicine, University of Rochester Medical Center
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Research
Oxidant and cigarette smoke-mediated lung inflammation.
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants.
Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.
研究兴趣
论文共 562 篇作者统计合作学者相似作者
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FASEB BIOADVANCESno. 2 (2024): 53-71
Journal of inflammation (London, England)no. 1 (2024): 9-9
Gagandeep Kaur,Md. Sohanur Rahman, Sadiya Shaikh,Kingshuk Panda,Srinivasan Chinnapaiyan, Maria Santiago Estevez, Li Xia,Hoshang Unwalla,Irfan Rahman
Biochemical Pharmacologypp.116179, (2024)
Rafael H Orfin, Victoria Uceda, Cody Gardner, Brianna Estrada, Edward Tamayo,Ruthmarie Hernández-Torres,Dongmei Li,Irfan Rahman,Scott McIntosh, Deborah J Ossip,Ana Paula Cupertino,Francisco Cartujano-Barrera
Gagandeep Kaur,Md Sohanur Rahman, Sadiya Shaikh,Kingshuk Panda,Srinivasan Chinnapaiyan, Maria Santiago Estevez, Li Xia,Hoshang Unwalla,Irfan Rahman
Biochemical pharmacologypp.116179-116179, (2024)
Gagandeep Kaur,Md. Sohanur Rahman, Sadiya Shaikh,Kingshuk Panda,Srinivasan Chinnapaiyan, Maria Santiago Estevez, Li Xia,Hoshang Unwalla,Irfan Rahman
Biochemical Pharmacology (2024)
Online journal of public health informatics (2024): e53245-e53245
Ahmad El-Hellani, Ayomipo Adeniji,Hanno C Erythropel,Qixin Wang,Thomas Lamb,Vladimir B Mikheev,Irfan Rahman,Irina Stepanov,Robert M Strongin,Theodore L Wagener,Marielle C Brinkman
Mark Chandy, Thomas Hill,Nerea Jimenez-Tellez,Joseph C. Wu, S. Emma Sarles,Edward Hensel,Qixin Wang,Irfan Rahman,Daniel J. Conklin
Current Oral Health Reportsno. 1 (2024): 30-39
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