基本信息
浏览量:2
职业迁徙
个人简介
Mechanism of Bone Growth and Repair: Despite decades of study, the mechanism by which a thin layer of cartilage, the epiphyseal growth plate, regulates long bone growth remains poorly understood. Our earlier observation that the oxygen tension is a potent regulator of chondrocyte activity and mediated by the oxygen sensitive transcription factor, HIF-1, provided a new understanding of the regulatory process. The recent finding that HIF-2 is required for chondrocyte maturation and that it serves to regulate a previously unrecognized step in the maturation pathway, autophagy, holds promise of providing new insights into phase co-ordination that is especially relevant to the growth process. Our ongoing studies are directed at examining the impact of these proteins on the maturation, the extent of hypertrophy and the induction of chondrocyte mineralization and apoptosis, as well as promoting the proliferation of new cells into the maturation cascade.
研究兴趣
论文共 218 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Emanuel J. Novais,Victoria A. Tran,Shira N. Johnston, Kayla R. Darris, Alex J. Roupas,Garrett A. Sessions,Irving M. Shapiro,Brian O. Diekman,Makarand V. Risbud
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn