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个人简介
I'm interested in understanding and predicting the relationships between the sequences, structures and functions of proteins, the evolutionary conservation of these features and their alterations upon mutations leading to diseases. To that aim, I develop original methodologies for sequence analysis, especially based on the HCA approach (see below). Together with other tools, these help revealing information into yet unexplored areas of computational biology. These are applied to the evolutionary analysis of protein domains and protein architectures, with a special interest in the analysis of orphan protein domains and in the discovery of new families of domains, which are not yet described. Topology-based methodologies are also developed to address fundamental issues about protein folding and protein interaction properties.
研究兴趣
论文共 343 篇作者统计合作学者相似作者
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CELL REPORTSno. 1 (2024): 113601-113601
Alexis Bertrand,Ibrahima Ba,Laetitia Kermasson, Vithura Pirabakaran, Noemie Chable,Elodie Lainey,Christelle Menard,Faten Kallel,Capucine Picard,Sondes Hadiji,Nathalie Coolen-Allou,Elodie Blanchard,
HUMAN MOLECULAR GENETICSno. 7 (2024): 612-623
Geoffroy Gaschignard,Maxime Millet, Apolline Bruley,Karim Benzerara, Manuela Dezi,Feriel Skouri-Panet,Elodie Duprat,Isabelle Callebaut
Murielle P. Serres,Ronan Shaughnessy,Sophie Escot, Hussein Hammich,Frederique Cuvelier,Audrey Salles,Murielle Rocancourt, Quentin Verdon, Anne-Lise Gaffuri,Yannick Sourigues, Gilles Malherbe,Leonid Velikovsky,
Developmental cellno. 22 (2023): 2477-+
Brian Sperelakis‐Beedham, Maureen Lopez,Emmanuelle Bourrat, Natacha Gaitch, Florence Houriez,Brigitte Martinez,Isabelle Fajac,Pierre‐Régis Burgel,Geoffroy Hickman,Marie‐Pierre Audrézet, Delphine Gonde, Faiza Cabet,
Journal of the European Academy of Dermatology and Venereology (2023)
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HUMAN MUTATION (2023): 1-22
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Rim Debbiche,Chandran Ka,Isabelle Gourlaouen, Sandrine Maestri,Kevin Uguen,Paul-Alain Jaffres,Isabelle Callebaut,Gerald Le Gac
biorxiv(2023)
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Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2023): S5-S11
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