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The long-term goal of my research program is identify potential therapies for aged-related conditions/disorders, including meno- and andropausal hot flushes, infertility, and neurodegenerative diseases, like Parkinson’s disease (PD), Alzheimer’s disease (AD) and cerebrovascular stroke. These goals encompass conducting translational research that will yield outcomes with tangible benefits to patients. One of my long-term goals is to evaluate neuroprotection by pituitary adenylate cyclase-activating polypeptide (PACAP38) and its metabolically stable analogs in animal models of neurodegenerative diseases. Another goal is to develop brain-selective estrogen therapy utilizing pro-drug approach. A third goal is to develop therapies for advanced aged women to increase their fertility.
I have been trained in anatomy/neuroendocrinology, with expertise in the key research areas necessary for this application. These include (but are not limited to) extensive expertise with several rodent models and techniques, including rodent surgeries (stereotaxic brain surgeries, endocrine- and reproduction-related surgeries), necropsies, histology, RT-PCR and in situ hybridization histochemistry, immunocytochemistry, and Western blot analysis. I have developed rodent models of focal and global ischemia, hot flush, and other aspects of female reproductive physiology and aging.
I have been trained in anatomy/neuroendocrinology, with expertise in the key research areas necessary for this application. These include (but are not limited to) extensive expertise with several rodent models and techniques, including rodent surgeries (stereotaxic brain surgeries, endocrine- and reproduction-related surgeries), necropsies, histology, RT-PCR and in situ hybridization histochemistry, immunocytochemistry, and Western blot analysis. I have developed rodent models of focal and global ischemia, hot flush, and other aspects of female reproductive physiology and aging.
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Hormones and Behavior (2024): 105524-105524
Molecular human reproductionno. 10 (2023)
Polymnia Georgiou,Ta-Chung M Mou,Liam E Potter,Xiaoxian An,Panos Zanos,Michael S Patton,Katherine J Pultorak,Sarah M Clark, Virn Ngyuyen,Chris F Powels, Katalin Prokai-Tartai,Istvan Merchenthaler,
biorxiv(2022)
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