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个人简介
We are interested in the regulation of growth and metabolism during cancer. Cancer is characterised by uncontrolled cell division - for cancer cells to be successful in proliferation, a major change is the up-regulation of growth pathways and the reorganisation of metabolism to produce the energy and building blocks necessary for cell division. We aim to identify novel alterations in cancer cells that are crucial for their proliferation and that distinguish them from normal cells, thereby uncovering potentially less harmful anti-cancer targets. In our research, we use the fruit fly Drosophila melanogaster, which has already greatly contributed to our understanding of cancer and the discovery of several cancer-related growth pathways. Many features of human cancer can be replicated in Drosophila. This model system has many advantages such as its short generation time, low gene redundancy, and powerful genetic techniques that allow the rapid testing of various hypotheses.
研究兴趣
论文共 37 篇作者统计合作学者相似作者
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Claudia Lennicke,Ivana Bjedov,Sebastian Grönke,Katja E. Menger,Andrew M. James, Jorge Iván Castillo-Quan, Lucie A. G. van Leeuwen,Andrea Foley, Marcela Buricova, Jennifer Adcott, Alex Montoya, Holger B. Kramer,
biorxiv(2024)
Victoria Eugenia Martinez-Miguel,Celia Lujan, Tristan Espie-Caullet,Daniel Martinez-Martinez,Saul Moore,Cassandra Backes,Suam Gonzalez,Evgeniy R Galimov,André E X Brown,Mario Halic,Kazunori Tomita,Charalampos Rallis,
Ivana Bjedov, Helena M Cochemé,Andrea Foley, Daniela Wieser,Nathaniel S Woodling, Jorge Iván Castillo-Quan,Povilas Norvaisas, Celia Lujan, Jennifer C Regan,Janne M Toivonen, Michael P Murphy,Janet Thornton,
user-5f8cf9244c775ec6fa691c99(2020)
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GENESno. 9 (2020): 1043
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