基本信息
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Cell Signalling
Bursts of intracellular calcium released from subcellular membrane compartments are a form of fast second messenger signaling mechanisms which control a range of cellular processes.
Such processes include the muscle contraction which governs the heartbeat, breathing and movement, downstream gene transcription and mobilization of secretory vesicular stores.
The temporal and spatial patterns of calcium release provide important contextual information to the target(s) of the signal. These are often provided by the organization, the regulation and interplay between the intracellular calcium release channels within these cells.
The most common types include the giant ryanodine receptors (RyRs) and the inositol triphosphate receptors (IP3Rs). As a cell biologist, I am interested in how the spatial organization and biochemical (post-translational) modification of these calcium handling proteins determine the calcium signals which can be observed within a range of cell types.
I use a combination of super-resolution imaging and live cell imaging modalities to interrogate how the cytoplasmic calcium signals may be spatially encoded in the way the sub-cellular ultrastructures are organized.
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FASEB JOURNALno. 5 (2024): e23535-e23535
Krisha Aghi, Brendan M. Anderson, Bria M. Castellano, Avery Cunningham,Maggie Delano, Evyn S. Dickinson,Lexy von Diezmann, Sofia Kirke Forslund-Startceva, Dori M. Grijseels, Sebastian S. Groh,Eartha Mae Guthman,Izzy Jayasinghe,
Thomas M. D. Sheard,Tayla B. Shakespeare,Rajpinder S. Seehra, Michael E. Spencer,Kin M. Suen,Izzy Jayasinghe
NANOSCALEno. 45 (2023): 18489-18499
Life science allianceno. 4 (2023): e202201650-e202201650
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Rajpinder S. Seehra,Samantha J. Warrington, Benjamin H. K. Allouis,Thomas M. D. Sheard,Michael E. Spencer,Tayla Shakespeare,Ashley Cadby, Daniel Bose,David Strutt,Izzy Jayasinghe
CELL REPORTS PHYSICAL SCIENCEno. 12 (2023): 101719
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1864 (2022): 20210316-20210316
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