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个人简介
My research studies concern the investigation of the molecular pathogenesis of myeloid malignancies, including the myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML).
My work has focused on MDS, a heterogeneous group of clonal myeloid disorders. My studies have been instrumental in the determination of the molecular pathogenesis of several subtypes of MDS including the 5q- syndrome and refractory anaemia with ring sideroblasts (RARS). Our research identified the commonly deleted region of the del(5q) in the 5q- syndrome and showed that p53 activation underlies the anaemia in this disorder.
Using next generation sequencing technology we have illuminated the molecular landscape of MDS and the genetic basis of disease progression to AML. Our study of the MDS transcriptome has yielded valuable insights into the molecular pathophysiology of MDS, and has identified new prognostic markers and therapeutic targets for this disorder. Our work has provided deep insights into how gene mutations drive the changes in the MDS transcriptome.
My work has focused on MDS, a heterogeneous group of clonal myeloid disorders. My studies have been instrumental in the determination of the molecular pathogenesis of several subtypes of MDS including the 5q- syndrome and refractory anaemia with ring sideroblasts (RARS). Our research identified the commonly deleted region of the del(5q) in the 5q- syndrome and showed that p53 activation underlies the anaemia in this disorder.
Using next generation sequencing technology we have illuminated the molecular landscape of MDS and the genetic basis of disease progression to AML. Our study of the MDS transcriptome has yielded valuable insights into the molecular pathophysiology of MDS, and has identified new prognostic markers and therapeutic targets for this disorder. Our work has provided deep insights into how gene mutations drive the changes in the MDS transcriptome.
研究兴趣
论文共 330 篇作者统计合作学者相似作者
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Advances in biological regulation (2024): 101014-101014
Sila Gerlevik, Shan Hama,Nogayhan Seymen, Warisha Mumtaz,Ian Richard Thompson, Seyed R Jalili, Deniz E Kaya,Alfredo Iacoangeli,Andrea Pellagatti,Jacqueline Boultwood,Giorgio Napolitani,Ghulam J. Mufti,
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Opeyemi Ajibade,Urszula Pakulska,Emma Rabinovich, Ariel Fromowitz,Srabani Sahu,Sarah Aminov,Nandini Ramachandra,Srinivas Aluri, Shanisha Gordon Mitchell,Milagros Carbajal, Kinga Keska-Izworska,Michal Combik,
BLOOD (2023)
crossref(2023)
Ariel Fromowitz,Srinivas Aluri, Jesus D. Gonzalez Lugo,Emma Rabinovich,Nandini Ramachandra,Sarah Aminov,Srabani Sahu, Shanisha Gordon Mitchell,Ritesh Aggarwal, Opeyemi Ajibade,Milagros Carbajal,Kith Pradhan,
BLOOD (2023): 5615
Cancer Researchno. 7_Supplement (2023): 6168-6168
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