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个人简介
My research program explores changes in DNA methylation in cancer and we were the first to demonstrate that tumor suppressor genes are silenced by promoter region methylation. We have characterized changes in methylation associated with the development and progression of cancer, including the demonstration of changes in DNA methylation in premalignant lesions. Current research is aimed at utilizing these findings to improve the management of patients through the development of prognostic, predictive, and early detection epigenetic biomarkers, and in studies of epigenetic therapy. We have developed new methods for study of DNA methylation (methylation specific PCR, in Situ MSP, ERMA, and more recently nanotechnology based detection methods, included MS-QFRET and MOB, DREAMing). These sensitive methods have been used for the early detection of cancer and for developing predictive biomarkers. I am a member of TCGA (The Cancer Genome Atlas) and have characterized genome wide epigenetic changes in cancer in multiple forms of cancer.
研究兴趣
论文共 686 篇作者统计合作学者相似作者
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Meiying Zhang,Xiaoyun Li,James G Herman,Aiai Gao, Qian Wang, Yuanxin Yao,Fangfang Shen,Kunlun He,Mingzhou Guo
Clinical and translational gastroenterologyno. 3 (2024): e00682-e00682
American journal of hematologyno. 3 (2024): 380-386
Cancer Researchno. 6_Supplement (2024): 6104-6104
Cancer Researchno. 6_Supplement (2024): 6551-6551
Cancer Researchno. 6_Supplement (2024): 7024-7024
Jian-Min Yuan,Thomas W. Kensler,Sanja Dacic, Douglas J. Harman,Renwei Wang, Paula Balogh, Lindsey Seigh, Yen T-H Pham,Jennifer Adams-Haduch, Shivendra Singh,James G. Herman,Avrum Spira,
Cancer Researchno. 6_Supplement (2024): 749-749
Emi Ota Machida,Malcolm V. Brock,Craig M. Hooker,Jun Nakayama,Akiko Ishida,Jun Amano,Maria A. Picchi,Steven A. Belinsky,James G. Herman, Shun'ichiro Taniguchi, Stephen B. Baylin
crossref(2023)
Debby M.E.I. Hellebrekers,Veerle Melotte,Emmanuelle Viré, Elise Langenkamp, Grietje Molema,François Fuks,James G. Herman,Wim Van Criekinge,Arjan W. Griffioen,Manon van Engeland
crossref(2023)
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 16 (2023)
crossref(2023)
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