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Research in the Van Etten laboratory focuses on the isolation and characterization of large icosahedral, dsDNA-containing, plaque-forming viruses that infect certain unicellular, eukaryotic chlorella-like green algae. These viruses are ubiquitous in freshwater from all over the world. The chlorella viruses have genomes as large as 370 kb that contain as many as 400 protein-encoding and 16 tRNA encoding genes. Besides their large genomes, the chlorella viruses have other unexpected features:
They encode multiple DNA methyltransferases and DNA restriction endonucleases.
Unlike other glycoprotein-containing viruses, chlorella viruses encode most, if not all, of the components required to glycosylate their proteins.
Many chlorella virus-encoded proteins are either the smallest or among the smallest proteins of their class.
Consequently, these proteins serve as models for mechanistic and structural studies. Infection by the chlorella viruses resembles bacterial infection by tailed bacteriophages in many respects.
They encode multiple DNA methyltransferases and DNA restriction endonucleases.
Unlike other glycoprotein-containing viruses, chlorella viruses encode most, if not all, of the components required to glycosylate their proteins.
Many chlorella virus-encoded proteins are either the smallest or among the smallest proteins of their class.
Consequently, these proteins serve as models for mechanistic and structural studies. Infection by the chlorella viruses resembles bacterial infection by tailed bacteriophages in many respects.
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Gary Pattee,Petro Thomas,Ahmed Esmael,Irina Agarkova,David Dunigan, Fabrizio Chiodo, Cristina de castro,James Van Etten
Virusesno. 4 (2023): 911-911
APPLIED AND ENVIRONMENTAL MICROBIOLOGYno. 12 (2023): e0165923-e0165923
JOURNAL OF VIROLOGYno. 5 (2023)
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MUSCLE & NERVEno. 17 (2023): S57-S57
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Gary Pattee,Thomas Petro,Rahmed Esmael,Irina Agarkova,David Dunigan, Fabrizio Chiodo, Cristina De Castro,James Van Etten
MUSCLE & NERVE (2023): S8-S9
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