Historically, the research in my laboratory looked at metabolic processes related to aerobic respiration in plants and fungi. Specifically, this research involves isolating and characterizing the structural and regulatory features of the cyanide-resistant "alternative" oxidase associated with all plant and many fungal mitochondria. The mechanism of action of a regulatory sulfhydryl-disulfide system on the alternative oxidase and its interplay with the activating effects of alpha-keto acids are currently under study, as is the characterization of structural features of the alternative protein and its active site.