基本信息
浏览量:158
职业迁徙
个人简介
Dr. Jan Holmgren, MD, PhD is Professor of Medical microbiology and immunology at University of Gothenburg, Sweden, a chair he took over in 1980 after Prof. Örjan Ouchterlony; he is also Director of the Göteborg University Vaccine Research Institute (GUVAX). JH has published more than 500 papers in the fields of microbiology, immunology and vaccinology, and he is an elected member of various societies and academies including e.g. the Swedish Royal Academy of Science and the Swedish Royal Academy of Engineering. He has also served on many national and international boards, e.g. on the Board of Directors of the Knut and Alice Wallenberg Foundation (Sweden), the International Vaccine Institute (IVI), and the Global Alliance for Vaccines and Immunization (GAVI), and he is a member of several international vaccine-related technical task forces or steering committees.
Scientifically, after completing his PhD thesis on urinary tract infection immunology in 1969, a large part of JH´s research has been focused on the mechanisms of disease and immunity in cholera and other mucosal infections and on the development of mucosal vaccines. In his early work on cholera, JH discovered, for instance, both the AB subunit structure and function of cholera toxin and the GM1 ganglioside as the cholera toxin receptor. JH and his coworkers have also made many important contributions in mucosal immunology and in the development of mucosal vaccines and adjuvants. They have developed and taken the oral B subunit-whole cell cholera vaccine all the way from basic concept to an internationally widely registered product, they have developed and taken an oral ETEC vaccine from concept to phase 3 trials, and they have pioneered the development of methods for assessment of mucosal vaccine immunogenicity in humans. In more basic aspects of mucosal vaccinology, JH´s laboratory has made important contributions in mucosal adjuvant construction, in defining basic mechanisms of mucosal immune regulation, and in developing promising mucosal immunomodulating/tolerogenic vaccine therapies against autoimmune and allergic diseases, the latter based on JH´s and Cecil Czerkinsky´s discovery of cholera toxin B subunit as a uniquely efficient combined carrier and immunomodulator for inducing peripheral T cell tolerance to chemically or genetically conjugated tissue antigens or allergens.
H has received numerous major scientific prizes and other distinctions for his research contributions, e g The Royal Swedish Academy of Science Prize in Medicine for 1977 (“Hilda and Alfred Erikssons pris”); The Anders Jahre Prize II (young scientists) in Medicine for 1982 (Norway); “Söderbergska Priset” (biggest Prize of The Swedish Medical Society) for 1994 ; The Louis Jeantet Prize for Medicine for 1994 (Switzerland); The Eric K. Fernström Big Nordic Prize in Medicine 2004 (Lund University, Sweden); and The International Society for Mucosal Immunology “Distinguished Science Achievement Award 2007 “ .
JH and his laboratory are extensively involved in collaborations with many international research institutions and programs, e.g. IVI, WHO, GAVI, and ICDDR,B (Bangladesh) and EU´s MUVAPRED program for mucosal vaccines.
Publications:
When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks?
John Clemens, Jan Holmgren
Cholera Outbreaks, Volume 379, Pages 231-258 2014
Journal Article, peer-reviewed Read the full text
on a web page Development of Stable Vibrio cholerae O1 Hikojima Type Vaccine Strains Co-Expressing the Inaba and Ogawa Lipopolysaccharide Antigens
Stefan Karlsson, Elisabeth Ax, Erik Nygren, Susanne Källgård, Margareta Blomquist et al.
Plos One, Volume 9, Issue 11, 2014
Journal Article, peer-reviewed Read the full text
on a web page Vibriocidal Antibody Responses to a Bivalent Killed Whole-Cell Oral Cholera Vaccine in a Phase III Trial in Kolkata, India
S. Kanungo, A. L. Lopez, M. Ali, B. Manna, D. R. Kim et al.
Plos One, Volume 9, Issue 5, 2014
Journal Article, peer-reviewed Read the full text
on a web page Expression of Cholera Toxin by El Tor Vibrio cholerae in Shallow Culture Growth Conditions
Mayra Cobaxin, Haydee Martinez, Guadalupe Ayala, Jan Holmgren, Åsa Sjöling et al.
Microbial Pathogenesis, Volume 66, Pages 5-13 2014
Journal Article, peer-reviewed
研究兴趣
论文共 604 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Manuela Terrinoni,Stefan L Nordqvist,Madeleine Löfstrand, Frida Nilsson,Susanne Källgård,Tarun Sharma, Michael R Lebens,Jan Holmgren
Vaccineno. 21 (2023): 3347-3357
Journal of travel medicine (2023)
Anu Kantele,Marianna Riekkinen,Jokiranta T Sakari, H Pakkanen Sari, Pietilä Jukka-Pekka,Anu Patjas,Mari Eriksson,Tamim Khawaja,Peter Klemets,Marttinen Kati,Siikamäki Heli,Anna Lundgren,
Journal of Travel Medicineno. 7 (2023)
Elsevier eBookspp.211-224.e5, (2023)
引用0浏览0引用
0
0
Elsevier eBookspp.286-297.e5, (2023)
引用0浏览0引用
0
0
The Lancet Infectious Diseasesno. 10 (2022): e292-e298
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn