基本信息
浏览量:24
职业迁徙
个人简介
Research
The Janetka research laboratory is broadly interested in the X-ray structure-based drug design, medicinal chemistry and organic synthesis of chemical tools and small molecule drugs. In multiple drug discovery projects, we are developing inhibitors of proteases, kinases, lectins, and other protein targets for studying and treating cancer and a variety of infectious disease. One project is targeting several serine proteases including HGFA and hepsin which activate growth factors and cytokines in tumors. Another project is working on inhibitors of transmembrane serine proteases such as TMPRSS2 and matriptase as broad-spectrum antiviral drugs. We have a project focused on aspartic protease inhibitors and GPCR antagonists as novel therapy for River Blindness, caused by parasitic filarial worm infections. We are also working on phosphodiesterase inhibitors as well as inhibitors of PIM kinase and others as new anthelmintic drugs to treat intestinal worm infections caused by whipworm and hookworm. Further studies are directed on the rational design of CDPK1 kinase inhibitors as novel drugs to treat acute and cure chronic Toxoplasmosis. Finally, a large research effort is dedicated to the structure-guided design of glycomimetic lectin antagonists such as PapG as innovative antivirulence therapeutics for the treatment and prevention of bacterial infections and in one project targeting Fap2 for colon cancer.
The Janetka research laboratory is broadly interested in the X-ray structure-based drug design, medicinal chemistry and organic synthesis of chemical tools and small molecule drugs. In multiple drug discovery projects, we are developing inhibitors of proteases, kinases, lectins, and other protein targets for studying and treating cancer and a variety of infectious disease. One project is targeting several serine proteases including HGFA and hepsin which activate growth factors and cytokines in tumors. Another project is working on inhibitors of transmembrane serine proteases such as TMPRSS2 and matriptase as broad-spectrum antiviral drugs. We have a project focused on aspartic protease inhibitors and GPCR antagonists as novel therapy for River Blindness, caused by parasitic filarial worm infections. We are also working on phosphodiesterase inhibitors as well as inhibitors of PIM kinase and others as new anthelmintic drugs to treat intestinal worm infections caused by whipworm and hookworm. Further studies are directed on the rational design of CDPK1 kinase inhibitors as novel drugs to treat acute and cure chronic Toxoplasmosis. Finally, a large research effort is dedicated to the structure-guided design of glycomimetic lectin antagonists such as PapG as innovative antivirulence therapeutics for the treatment and prevention of bacterial infections and in one project targeting Fap2 for colon cancer.
研究兴趣
论文共 130 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Robert Obermann, Bereket Yemane,Cassie Jarvis, Francisco M Franco, Yevhenii Kyriukha, William Nolan, Beth Gohara, Andrzej M Krezel,Scott A Wildman,James W Janetka
ChemMedChempp.e202300648-e202300648, (2024)
Vivian Truong Jones,Ramona Graves-Deal,Zheng Cao,Galina Bogatcheva,Marisol A. Ramirez, Sarah J. Harmych,James N. Higginbotham, Claudia C. Wahoski, Neeraj Joshi,Joseph T. Roland, Gregory D. Ayers,Qi Liu,
Cancer Researchno. 6_Supplement (2024): 2001-2001
JOURNAL OF MEDICINAL CHEMISTRYno. 6 (2024): 4833-4854
Robert Obermann, Bereket Yemane,Cassie Jarvis, Francisco M. Franco, Yevhenii Kyriukha,William Nolan, Beth Gohara, Andrzej M. Krezel,Scott A. Wildman,James W. Janetka
CHEMMEDCHEM (2024)
Adrianus C M Boon,Traci L Bricker,Ethan J Fritch,Sarah R Leist,Kendra Gully,Ralph S Baric,Rachel L Graham, Brigid V Troan, Matthew Mahoney,James W Janetka
MOLECULAR ONCOLOGYno. 3 (2024): 547-561
Vivian Truong Jones,Ramona Graves-Deal,Zheng Cao,Galina Bogatcheva,Marisol A. Ramirez, Sarah J. Harmych,James N. Higginbotham, Vineeta Sharma,Vishnu C. Damalanka, Claudia C. Wahoski, Neeraj Joshi, Maria Johnson Irudayam,
Cellular and molecular life sciences : CMLSno. 1 (2024): 28-28
Cancer letters (2023): 216286-216286
Vivian T. Jones,Ramona Graves‐Deal,KyuOK Jeon, Adam J. Rosenberg,Zheng Cao,Galina Bogatcheva, Sarah J. Harmych,James N. Higginbotham,Kwang‐Ho Kim,James W. Janetka,Gary A. Sulikowski,Bhuminder Singh
Cancer Researchno. 7_Supplement (2023): 2562-2562
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn