To do this, they develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods for single-cell ATAC-seq, an increasingly popular method to measure the epigenomes of single-cells. Altogether, we broadly apply these tools to study dynamic cellular systems, including the epigenetic mechanisms underlying cell fate decisions in hematopoiesis and leukemia development.

ATAC-seq was first developed by Buenrostro and colleagues in 2013 and its use is now ubiquitous in genomics — for example in major efforts like the Human Cell Atlas project to understand and map genome function. As a reflection of the impact of this work, MIT’s Technology Review named Buenrostro as one of its 2019 “Innovators under 35”.