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I am interested in the way in which experience instantiates itself into the physical structure of neural circuits, that is the physical underpinning of long lasting memory. During mammalian development synaptic connectivity changes dramatically as axons trim many of the synaptic branches and target cells loose many of their synaptic partners while at the same time the subset of connections that remain become stronger. It is possible that these changes underlie the way experience selects from a broad range of synaptic connections a small subset to underlie a long lasting trace of an experience. Our work argues that competition between the neurons that co-innervate the same target cells in development may drive these changes in connectivity. The lab studies circuit formation and rearrangement by visualizing peripheral (motor and autonomic) synaptic circuits directly in living animals. These studies take advantage of transgenic animals in which we express different colored fluorescent proteins in each cell (Brainbow). In addition we have developed automated tools to map neural connections (connectomics) at nanometer resolution using a new method of serial electron microscopy. This latter approach gives of a means of revealing neural circuit motifs throughout the nervous system.
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论文共 232 篇作者统计合作学者相似作者
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Hongyu Ge, Jiahao Shi,Shuohong Wang,Donglai Wei,Jiancheng Yang,Ao Cheng,Richard Schalek, Jun Guo,Jeff Lichtman,Lirong Wang,Ruobing Zhang
Computers in Biology and Medicinepp.108456, (2024)
CVPR Workshopspp.4273-4284, (2023)
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Xiaotang Lu,Yuelong Wu,Peter Li,Tao Fang,Richard L. Schalek, Yaxin Su, Jeffery D. Carter,Shashi Gupta,Viren Jain,Nebojsa Janjic,Jeff W. Lichtman
bioRxiv : the preprint server for biology (2023)
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bioRxiv : the preprint server for biology (2023)
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Cell reports methodsno. 7 (2023): 100520-100520
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Elisa C Pavarino, Emma Yang,Nagaraju Dhanyasi, Mona Wang,Flavie Bidel,Xiaotang Lu,Fuming Yang,Core Francisco Park, Mukesh BR, Brandon Drescher,Aravinthan D.T. Samuel,Binyamin Hochner,
Diégo Cordero Cervantes,Harshavardhan Khare,Alyssa Michelle Wilson, Nathaly Dongo Mendoza, Orfane Coulon-Mahdi,Jeff William Lichtman,Chiara Zurzolo
Science Advancesno. 14 (2023)
Xiaomeng Han,Peter H Li,Shuohong Wang, Morgan Sanchez, Sneha Aggarwal, Tim Blakely,Richard Schalek,Yaron Meirovitch,Zudi Lin, Daniel Berger,Yuelong Wu, Fatima Aly,
bioRxiv : the preprint server for biology (2023)
Diégo Cordero Cervantes,Harshavardhan Khare,Alyssa Michelle Wilson, Nathaly Dongo Mendoza, Orfane Coulon--Mahdi,Jeff William Lichtman,Chiara Zurzolo
biorxiv(2022)
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