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Work on aldehyde oxidase (AO)- AO continues to be of increasing importance in drug metabolism and an early understanding of binding and kinetics will help us avoid expensive failures in the clinic. Such failures have already been documented for AO, and a general awareness of the problem now exists. However, models for AO’s role in human metabolism are particularly significant since animal models fail to predict human AO (hAO) affinities or clearance values. The major impact of this research will be in decreasing drug development time and the cost in human life associated with incomplete information when a drug candidate enters clinical trials.
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Papers共 192 篇Author StatisticsCo-AuthorSimilar Experts
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NATURE COMMUNICATIONSno. 1 (2024)
Paras S. Minhas,Jeffrey R. Jones,Amira Latif-Hernandez,Yuki Sugiura,Aarooran S. Durairaj,Qian Wang,Siddhita D. Mhatre,Takeshi Uenaka,Joshua Crapser, Travis Conley,Hannah Ennerfelt,Yoo Jin Jung, Ling Liu,Praveena Prasad,Brenita C. Jenkins, Yeonglong Albert Ay, Matthew Matrongolo,Ryan Goodman, Traci Newmeyer,Kelly Heard,Austin Kang,Edward N. Wilson,Tao Yang,Erik M. Ullian,Geidy E. Serrano,Thomas G. Beach,Marius Wernig,Joshua D. Rabinowitz,Makoto Suematsu,Frank M. Longo,Melanie R. McReynolds,Fred H. Gage,Katrin I. Andreasson
SCIENCEno. 6711 (2024)
Cancer Researchno. 6_Supplement (2024): 1639-1639
Bang-An Wang,Jeffrey R. Jones,Jingtian Zhou,Wei Tian, Yue Wu,Wenliang Wang,Peter Berube,Anna Bartlett,Rosa Castanon,Joseph R. Nery,Huaming Chen,Mia Kenworthy,Jordan Altshul,Cynthia Valadon,Yichen Wang,Austin Kang,Ryan Goodman,Michelle Liem,Naomi Claffey,Caz O’Connor, Jeffrey Metcalf,Chongyuan Luo,Fred H. Gage,Joseph R. Ecker
biorxiv(2023)
NATURE REVIEWS NEUROLOGYno. 7 (2023): 434-443
Andreea Manole,Thomas Wong, Amanda Rhee, Sammy Novak, Shao-Ming Chin, Katya Tsimring, Andres Paucar,April Williams, Traci Fang Newmeyer,Simon T. Schafer,Idan Rosh,Susmita Kaushik, Rene Hoffman,Songjie Chen,Guangwen Wang,Michael Snyder,Ana Maria Cuervo,Leo Andrade,Uri Manor,Kevin Lee,Jeffrey R. Jones,Shani Stern,Maria C. Marchetto,Fred H. Gage
CELL REPORTSno. 12 (2023)
openalex(2021)
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Author Statistics
#Papers: 192
#Citation: 9097
H-Index: 51
G-Index: 89
Sociability: 7
Diversity: 3
Activity: 1
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