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The research in the group of Sun involves investigation of B cell development and B cell related diseases. In recent years, immunotherapies with antibodies to depleting B cells are widely used in autoimmune diseases and B cell lymphoma. The strategy in this group is to design cytokine antagonist peptides using computer-aided design, fuse the peptides with human IgG Fc to form peptibodies by gene engineering, and analyze their activity in vitro and in vivo. Several peptibodies inhibiting B lymphocyte stimulator (BLyS), a critical factor for B cell maturation and survival, are currently tested in cell culture and SLE animal models in this lab. Because overexpression of BLyS is involved in pathogenesis and development of autoimmune diseases and B cell malignances, the BLyS antagonists designed and analyzed may be potential therapeutic reagents for these diseases.
The research in the group of Sun involves investigation of B cell development and B cell related diseases. In recent years, immunotherapies with antibodies to depleting B cells are widely used in autoimmune diseases and B cell lymphoma. The strategy in this group is to design cytokine antagonist peptides using computer-aided design, fuse the peptides with human IgG Fc to form peptibodies by gene engineering, and analyze their activity in vitro and in vivo. Several peptibodies inhibiting B lymphocyte stimulator (BLyS), a critical factor for B cell maturation and survival, are currently tested in cell culture and SLE animal models in this lab. Because overexpression of BLyS is involved in pathogenesis and development of autoimmune diseases and B cell malignances, the BLyS antagonists designed and analyzed may be potential therapeutic reagents for these diseases.
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Journal of Molecular Modelingno. 10 (2022): 1-11
Lung cancer (Amsterdam, Netherlands) (2021): 105-112
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