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哈佛医学院神经疾病中心神经学教授、美国布莱根妇女医院高级研究员、上海交通大学“长江学者奖励计划”特聘讲座教授和“千人计划”教授。
Jie Shen is Professor of Neurology at Harvard Medical School and Director of the Udall Center of Excellence for Parkinson's Disease at Brigham and Women's Hospital. She received her Ph.D. in molecular biology from the University of Virginia in 1995 studying the mechanisms of alternative splicing in Drosophila. As a postdoctoral fellow at MIT, she began the investigation of the molecular basis of Alzheimer’s disease using mouse genetic approaches. Since 1998, she has directed a molecular neurobiology laboratory whose major research interests focus on the pathogenesis of Alzheimer’s and Parkinson’s diseases. Her genetic studies have led to the proposal of the Presenilin Hypothesis, which posits that loss of presenilin function underlies neurodegeneration and dementia in the pathogenesis of Alzheimer’s disease. Her genetic analysis of gene products involved in Alzheimer’s and Parkinson’s diseases unexpectedly revealed that presynaptic defects in neurotransmitter release might underlie age-related neurodegeneration in these neurological disorders. The Udall Center she directs focuses on the role of LRRK2 and alpha-synuclein on the pathogenesis of Parkinson's disease.
Jie Shen is Professor of Neurology at Harvard Medical School and Director of the Udall Center of Excellence for Parkinson's Disease at Brigham and Women's Hospital. She received her Ph.D. in molecular biology from the University of Virginia in 1995 studying the mechanisms of alternative splicing in Drosophila. As a postdoctoral fellow at MIT, she began the investigation of the molecular basis of Alzheimer’s disease using mouse genetic approaches. Since 1998, she has directed a molecular neurobiology laboratory whose major research interests focus on the pathogenesis of Alzheimer’s and Parkinson’s diseases. Her genetic studies have led to the proposal of the Presenilin Hypothesis, which posits that loss of presenilin function underlies neurodegeneration and dementia in the pathogenesis of Alzheimer’s disease. Her genetic analysis of gene products involved in Alzheimer’s and Parkinson’s diseases unexpectedly revealed that presynaptic defects in neurotransmitter release might underlie age-related neurodegeneration in these neurological disorders. The Udall Center she directs focuses on the role of LRRK2 and alpha-synuclein on the pathogenesis of Parkinson's disease.
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