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个人简介
The focus of Dr Liu's research efforts has been to understand neurobiological mechanisms of drug addiction and discover the targets for screening and developing drugs that have high analgesic activity and low addictive liability for treatment of pain and drug addiction. Current research area focuses on the cellular and molecular mechanisms underlying opioid tolerance and dependence. Ongoing projects involve 1) study on the way in which opioid receptors transduce their signals following; (1) acute receptor stimulation, (2) adaptation in response to chronic drug exposure; 2) study on the effects of chronic opioid treatment on the protein expression of certain brain regions which are associated with the development of opioid dependence and the role of alteration in protein expression in the development of opiod dependence as well as the epigenetic mechanisms underlying alteration of these protein expression following chronic opioid exposure; 3) study on the relationship between behavioral adaptations and synaptic structure and function plasticity induced by chronic exposure to opiates; 4) study on the mechanisms by which chronic opiate treatment contributes to changes in synaptic structure and function plasticity in certain brain areas associated with drug addiction; 5) study on Screen and discovery of high intrinsic activity but have low dependence potential kappa-opioid receptor ligands.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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BIOMEDICINE & PHARMACOTHERAPY (2024): 115957-115957
Acta Pharmacologica Sinicano. 5 (2024): 1-14
Journal of Molecular Neuroscienceno. 1 (2024): 1-12
Zixiang Li, Rufeng Ye,Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun,Siyuan Tang, Shuyang Hu,Jingrui Chai,Linghui Kong, Xiaoning Liu,Jing Chen,
Zixiang Li, Rufeng Ye,Qian He, Jiashuo Lu, Yanting Sun, Xiujian Sun,Siyuan Tang, Shuyang Hu,Jingrui Chai,Linghui Kong, Xiaoning Liu,Jing Chen,
CNS NEUROSCIENCE & THERAPEUTICS (2023)
Yu-Jun Wang,Gui-Ying Zan,Cenglin Xu,Xue-Ping Li,Xuelian Shu,Song-Yu Yao, Xiao-Shan Xu,Xiaoyun Qiu, Yexiang Chen, Kai Jin,Qi-Xin Zhou,Jia-Yu Ye,
Nature Communicationsno. 1 (2023): 1-17
CNS neuroscience & therapeutics (2023)
Research Square (Research Square) (2023)
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