In my 5 year Laureate Fellowship I will be researching new approaches to engineering software systems that fully take into account the "human" aspects of end users and team members. This project aims to find fundamentally new ways to capture and use human-centric software requirements during model-driven software engineering and verifying that systems meet these requirements. There are major issues with misaligned software applications in terms of accessibility, usability, emotions, personality, age, gender, and culture. We aim to address these through new conceptual foundations and modelling techniques for their support during software engineering. The intended outcomes are enhanced theory, models, tools and capability for next-generation software engineering with these critical elements. Significant benefits are expected to include greatly improved software quality, developer productivity and cost savings.