基本信息
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个人简介
Dr. Wherry’s expertise focuses on T cell exhaustion in chronic infections and cancer and on the mechanisms by which immunoregulatory “checkpoint” pathways such as PD-1 control T cell exhaustion. Dr. Wherry’s work has defined the molecular mechanisms of T cell exhaustion, including defining the role of inhibitory receptor biology, transcriptional control and regulation of T cell differentiation. This work has helped define key principles about inhibitory receptor blockade and co-blockade to reverse T cell exhaustion (e.g. coblockade of PD-1 and LAG3, etc). Work on combination treatment to reverse exhaustion is now being extended to include other complementary approaches such as radiation and other “orthogonal” treatments. Moreover, Dr. Wherry’s work has defined central transcriptional pathways including those controlled by Blimp-1, T-bet and Eomes in the biology of exhausted T cells. Major efforts continue in transcriptional profiling, genomics and computational biology and multiparameter flow cytometry to understand the nature and reversibility of T cell exhaustion in preclinical and clinical settings.
研究兴趣
论文共 10 篇作者统计合作学者相似作者
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The Journal of Immunologyno. 1_Supplement (2019): 189.17-189.17
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openalex(2015)
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The Journal of Immunologyno. 1_Supplement (2009): 44.5-44.5
JOURNAL OF IMMUNOLOGYno. 6 (2008): 3804.0-3810.0
JOURNAL OF IMMUNOLOGYno. SUPnan (2006): S124-S125
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作者统计
#Papers: 10
#Citation: 111
H-Index: 3
G-Index: 10
Sociability: 4
Diversity: 0
Activity: 0
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