Research Interest
CMV infection remains the most common infection in lung transplant recipients (LTRs) and a major cause of morbidity and mortality. Dr McDyer’s research investigates T-bet, the T cell transcriptional factor to determine if it is necessary for protective CMV-specific immunity during acute and chronic CMV infection. To test this he uses both the murine CMV (MCMV) pulmonary infection model and the LTR cohort to study the role of T-bet in pulmonary and systemic CMV host defense and the development of protective T cell memory.