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John Gerhart is a professor of the graduate school in the Department of Molecular and Cell Biology. His research group studies the early development of the amphibian Xenopus laevis, particularly the development of Spemann's organizer, which induces most dorsal and anterior structures of the embryonic body axis, those most characteristic of the chordate phylum.
They study cortical rotation, a 30° shift of the surface layer of the single-celled egg relative to the cytoplasmic core during the first cell cycle after fertilization. The direction of rotation is predictive of the site in the egg from which the organizer and dorsal structures develop. If rotation is blocked, the egg forms no organizer and develops as a radially symmetric "invertebrate" embryo with only a gut, red blood cells, and a ciliated epidermis. A dense array of parallel microtubules, which forms in the vegetal cortex of the normal egg, serves as tracks for rotation of the cortex. Rotation aligns these microtubules. Vesicles, organelles, and presumably informational molecules move along the array, from the vegetal pole to the equator on the future clorsal side. They seek to identity of the key vegetal materials (a beta-catenin-stabilizing agent is the current leading candidate) and in the means of transport.
They study cortical rotation, a 30° shift of the surface layer of the single-celled egg relative to the cytoplasmic core during the first cell cycle after fertilization. The direction of rotation is predictive of the site in the egg from which the organizer and dorsal structures develop. If rotation is blocked, the egg forms no organizer and develops as a radially symmetric "invertebrate" embryo with only a gut, red blood cells, and a ciliated epidermis. A dense array of parallel microtubules, which forms in the vegetal cortex of the normal egg, serves as tracks for rotation of the cortex. Rotation aligns these microtubules. Vesicles, organelles, and presumably informational molecules move along the array, from the vegetal pole to the equator on the future clorsal side. They seek to identity of the key vegetal materials (a beta-catenin-stabilizing agent is the current leading candidate) and in the means of transport.
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Sébastien Darras,Jens H Fritzenwanker, Kevin R Uhlinger, Ellyn Farrelly,Ariel M Pani, Imogen A Hurley,Rachael P Norris, Michelle Osovitz,Mark Terasaki,Mike Wu,Jochanan Aronowicz,Marc Kirschner,
Yale University Press eBookspp.109-142, (2017)
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Yale University Press eBookspp.10-37, (2017)
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CONCEPTUAL CHANGE IN BIOLOGY: SCIENTIFIC AND PHILOSOPHICAL PERSPECTIVES ON EVOLUTION AND DEVELOPMENT (2015): 175-197
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