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个人简介
John is a pioneer in the translation of basic science theory into clinical trials for lethal prostate cancer. Decades ago, he began doing science that no one else was attempting: finding ways to exploit the body’s process of apoptosis (basically, cellular suicide) as a means of killing metastatic prostate cancer.
In pioneering studies with Coffey, he showed that resistance to androgen deprivation occurs because of clonal selection: that androgen-resistant cells continue to grow, unfazed by hormonal therapy, and eventually overtake the hormone-sensitive cells. In subsequent studies, he and colleagues defined the mechanism by which androgen deprivation kills cells through apoptosis, and then provided evidence for a metastasis suppressor gene.
In pioneering studies with Coffey, he showed that resistance to androgen deprivation occurs because of clonal selection: that androgen-resistant cells continue to grow, unfazed by hormonal therapy, and eventually overtake the hormone-sensitive cells. In subsequent studies, he and colleagues defined the mechanism by which androgen deprivation kills cells through apoptosis, and then provided evidence for a metastasis suppressor gene.
研究兴趣
论文共 354 篇作者统计合作学者相似作者
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PROSTATEno. 1 (2024): 100-110
Sumer Jasmine, Adel Mandl,Timothy E. G. Krueger,Susan L. Dalrymple,Lizamma Antony, Jennifer Dias,Cassandra A. Celatka,Amy E. Tapper,Maria Kleppe,Mayuko Kanayama,Yuezhou Jing,Valentina Speranzini,Yuzhuo Z. Wang,Jun Luo,Bruce J. Trock,Samuel R. Denmeade,Michael A. Carducci,Andrea Mattevi,Hugh Y. Rienhoff Jr,John T. Isaacs,W. Nathaniel Brennen
The Prostate/The prostateno. 10 (2024): 909-921
crossref(2023)
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openalex(2023)
crossref(2023)
Rajendra Kumar,Janet Mendonca,Olutosin Owoyemi,Kavya Boyapati,Naiju Thomas,Suthicha Kanacharoen,Max Coffey,Deven Topiwala,Carolina Cavaliéri Gomes,Büşra Ozbek,Tracy Jones,Marc A. Rosen,Dong Liang,Sadie Wiens,W. Nathaniel Brennen,John T. Isaacs,Angelo M. De Marzo,Mark C. Markowski,Emmanuel S. Antonarakis,David Z. Qian,Kenneth J. Pienta, Drew M. Pardoll, Michael A. Carducci,Samuel R. Denmeade,Sushant K. Kachhap
openalex(2023)
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#Papers: 351
#Citation: 24809
H-Index: 86
G-Index: 152
Sociability: 7
Diversity: 1
Activity: 1
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