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The nuclear envelope is a regulated membrane barrier that separates the nucleus from the cytosol in eukaryotes. Although the NE is often depicted as a static barrier, new research has identified conditions where nuclear envelope rupturing causes a loss of compartmentalization. Nuclear envelope ruptures are rapidly repaired in the nucleus, but persist at aberrant, nuclear compartments, such as micronuclei and DNA bridges, that form around mis-segregated chromosomes. Compromised nuclear compartmentalization can result in DNA damage, inflammation, and clustered mutagenesis. The Maciejowski lab seeks to understand how the nuclear envelope safeguards the genome and prevents immune recognition of chromosomal DNA. We approach these problems using a combination of cell biology, biochemistry, and genomics.
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论文共 48 篇作者统计合作学者相似作者
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MOLECULAR CELLno. 5 (2024): 819-821
Eléonore Toufektchan,Alexandra Dananberg, Josefine Striepen, James H Hickling, Abraham Shim, Yanyang Chen, Ashley Nichols, Mercedes A Duran Paez,Lisa Mohr,Samuel F Bakhoum,John Maciejowski
Cancer immunology research (2024)
Molecular Cellno. 5 (2024): 819-821
Methods in Cell Biology (2024): 313-327
John Maciejowski, Taha Mohamed
Nature cancerpp.1-3, (2024)
bioRxiv : the preprint server for biology (2024)
Margo Coxon, Madeline A. Dennis,Alexandra Dananberg,Christopher D. Collins, Hannah E. Wilson, Jordyn Meekma,Marina Savenkova, Daniel Ng,Chelsea A. Osbron,Tony M. Mertz,Alan G. Goodman,Sascha H. Duttke,
NAR cancerno. 4 (2023): zcad058-zcad058
Albert S. Agustinus,Duaa Al-Rawi,Bhargavi Dameracharla,Ramya Raviram, Bailey S. C. L. Jones,Stephanie Stransky,Lorenzo Scipioni,Jens Luebeck,Melody Di Bona, Danguole Norkunaite,Robert M. Myers,Mercedes Duran,
Natureno. 7968 (2023): 176-183
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Albert S. Agustinus,Ramya Raviram, Bhargavi Dameracharla,Jens Luebeck, Stephanie Stransky,Lorenzo Scipioni, Robert M. Myers, Melody Di Bona, Mercedes Duran, Britta Weigelt,Shira Yomtoubian,Eleonore Toufektchan,
Cancer Researchno. 12_Supplement (2022): 3768-3768
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