基本信息
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职业迁徙
个人简介
Research Interests
Brain and body interactions as they relate to modulation of peripheral physiological systems and behavior. This includes neuroendocrine regulation of gene expression in inflammatory and immune responses, and stress-induced susceptibility to infectious and malignant diseases.
Research Summary
Research in my lab is directed towards understanding the pathways by which information from the central nervous system is transmitted to the periphery and affects physiological responses. Studies in the laboratory have defined a number of cellular and molecular mechanisms by which environmental factors, such as stress, affect the immune response. Recently, using a model of social stress, my lab has shown that exposure to repeated defeat, induces glucocorticoid resistance. Myeloid cells in the spleen and liver of socially-stressed, subordinate animals become insensitive to regulation by glucocorticoid hormones. These studies have demonstrated the importance of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system on innate and adaptive immune responses. This research has been supported by the NIH (NIDCR, NIMH, NIA, NHBLI, and NIAID), and the John D. and Catherine T. MacArthur Foundation.
Brain and body interactions as they relate to modulation of peripheral physiological systems and behavior. This includes neuroendocrine regulation of gene expression in inflammatory and immune responses, and stress-induced susceptibility to infectious and malignant diseases.
Research Summary
Research in my lab is directed towards understanding the pathways by which information from the central nervous system is transmitted to the periphery and affects physiological responses. Studies in the laboratory have defined a number of cellular and molecular mechanisms by which environmental factors, such as stress, affect the immune response. Recently, using a model of social stress, my lab has shown that exposure to repeated defeat, induces glucocorticoid resistance. Myeloid cells in the spleen and liver of socially-stressed, subordinate animals become insensitive to regulation by glucocorticoid hormones. These studies have demonstrated the importance of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system on innate and adaptive immune responses. This research has been supported by the NIH (NIDCR, NIMH, NIA, NHBLI, and NIAID), and the John D. and Catherine T. MacArthur Foundation.
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Ethan J. Goodman, Rebecca G. Biltz, Jonathan M. Packer,Damon J. DiSabato,Samuel P. Swanson, Braeden Oliver,Ning Quan,John F. Sheridan,Jonathan P. Godbout
Molecular Psychiatrypp.1-14, (2024)
Rebecca G. Biltz, Samuel P. Swanson, Natalie Draime, Amara C. Davis,Wenyuan Yin,Ethan J. Goodman, Natalie R. Gallagher,Anindya Bhattacharya,John F. Sheridan,Jonathan P. Godbout
Elsevier eBookspp.53-63, (2024)
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Mohammad Sendi,Zening Fu,Nathaniel Harnett,Sanne van Rooij, Victor Vergara,Diego Pizzagalli,Nikolaos Daskalakis,Stacey House,Francesca Beaudoin,Xinming An,Thomas Neylan,Gari Clifford,
Research square (2024)
Nature Mental Healthpp.1-14, (2024)
Psychological medicineno. 2 (2023): 1-12
Journal of affective disorders (2023): 1-9
L. D. Otto-Dobos, J. C. Santos, L. D. Strehle, C. V. Grant, L. A. Simon, B. Oliver,J. P. Godbout,J. F. Sheridan,R. M. Barrientos, E. R. Glasper,L. M. Pyter
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