基本信息
浏览量:0
职业迁徙
个人简介
We are interested in the fundamental signaling pathways responsible for cellular growth in the skin. Cellular growth in the skin can occur in response to immune mediators as in psoriasis, as a result of infection with viruses as in verruca vulgaris, and secondary to UV radiation and DNA damage as in skin cancer. One signaling pathway known to have a key role in cellular growth in all mammalian cells is the cAMP pathway. We study a novel source of cAMP in mammalian cells discovered 10 years ago called soluble adenylyl cyclase (sAC). This enzyme is unique in that it is present throughout the cell including the nucleus and mitochondria and, unlike other mammalian adenylyl cyclases, is not tethered to the plasma membrane. Investigation of this enzyme has proven useful for understanding the pathogenesis of diseases in organs such as the pancreas, kidney, brain, lung, and testes. We are currently exploring the role of this enzyme in pathogenesis of diseases of keratinocytes and melanocytes. In addition, we study the subcellular localization of this enzyme as a potential diagnostic for melanocytic proliferations.
研究兴趣
论文共 28 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Shawn Afvari,Jonathan H. Zippin
JAAD Case Reports (2024): 47-49
Journal of the American Academy of Dermatologyno. 5 (2024): 1071-1074
Journal of Investigative Dermatologyno. 8 (2022): S111-S111
Jakyung Bang,Jonathan H. Zippin
PIGMENT CELL & MELANOMA RESEARCHno. 1 (2021): 28-43
PIGMENT CELL & MELANOMA RESEARCHno. 4 (2021): 730-747
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn