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Jon Hoggatt's research group is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages. The lab also has a specific interest in translational science for bone marrow transplantation and other treatments.
Hoggatt and his colleagues have identified a unique "highly engraftable" hematopoietic stem cell that is currently being investigated and has applications for further probing of stem cell niche biology and clinical applications in stem cell transplantation, gene therapy, and other fields. The lab has also developed unique genetic mouse models allowing for the dynamic exploration of macrophage heterogeneity in a variety of disease settings.
Hoggatt and his colleagues have identified a unique "highly engraftable" hematopoietic stem cell that is currently being investigated and has applications for further probing of stem cell niche biology and clinical applications in stem cell transplantation, gene therapy, and other fields. The lab has also developed unique genetic mouse models allowing for the dynamic exploration of macrophage heterogeneity in a variety of disease settings.
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Chunxiao Zhang, Brenda Loera,Jianying Zhang, Richard Gelinas,Youmna Kfoury,Jonathan Hoggatt,Guido Marcucci,Pamela S. Becker
BLOOD (2023): 7122
David Alvarez, Guillemette Masse-Ranson,Saikiran K Sedimbi, Phylicia Wisti, Lisa Rodriguez, Jordan Santana,Taylor Manning, Tim Towner,Ben Geilich,Cosmin Mihai,Ankita Mishra,Sushma Gurumurthy,
biorxiv(2022)
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Kevin A. Goncalves,Sharon L. Hyzy, Katelyn J. Hammond,Patrick C. Falahee, Haley Howell,Jan Pinkas, Veit Schmelmer,Jonathan G. Hoggatt,David T. Scadden,Steven M. Devine,John F. DiPersio,William J. Savage,
Transplantation and Cellular Therapyno. 3 (2021)
Burger's Medicinal Chemistry and Drug Discoverypp.1-42, (2021)
J. Dipersio,S. Devine,J. Hoggatt,D. Scadden, H. Howell, V. Schmelmer, J. Neale, T. Boitano,M. Cooke, D. Morrow, G. Raffel,W. Savage,
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